Transcode Therapeutics, Inc.

On April 24, 2026, Wheeler Bio, Inc. (“Wheeler”) filed a complaint in the Supreme Court of the State of New York, County of New York, captionedWheeler Bio, Inc. v. Polynoma LLC, et al., No. 652458/2026 against Polynoma and us (the “Wheeler Action”). The Wheeler Action asserts two causes of action: breach of contract against Polynoma and intentional interference with contractual relations against us. The claims arise out of an agreement between Wheeler and Polynoma for certain contract development and manufacturing services offered by Wheeler. Wheeler alleges that, on October 1, 2025, Polynoma terminated a Statement of Work and a Change Order effective immediately without advance notice required by the agreement, and has failed to pay certain delay fees, cancellation fees, and invoices generated in connection with the agreement. Wheeler further alleges that we caused Polynoma to terminate the agreement and to refuse to pay the fees at issue. The Wheeler Action seeks compensatory and punitive damages, restitution, pre- and post-judgment interest, and attorneys’ fees and costs. We dispute the claims and intend to defend vigorously against this litigation.