IRONWOOD PHARMACEUTICALS INC

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No. )

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Preliminary Proxy Statement

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Definitive Proxy Statement

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Definitive Additional Materials

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Soliciting Material under §240.14a-12

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100 Summer Street, Suite 2300

Boston, Massachusetts 02110

NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS OF

We will also consider action on any other matter that may be properly brought before the meeting or any postponement(s) or adjournment(s) thereof.

Our board of directors recommends you vote “for” each of the eight nominees for director (proposal no. 1), “for” the advisory vote on named executive officer compensation (proposal no. 2), “for” the approval of the amendment to the Ironwood Pharmaceuticals, Inc. Amended and Restated 2019 Equity Incentive Plan (proposal no. 3) and “for” ratification of our selection of auditors (proposal no. 4). Only stockholders of record at the close of business on April 21, 2026, are entitled to notice of and to vote at the meeting.

We are pleased to take advantage of the Securities and Exchange Commission, or SEC, rules that allow us to furnish proxy materials to our stockholders on the internet. We believe these rules allow us to provide you with the information that you need while lowering the costs of delivery and reducing the environmental impact of the annual meeting.

Our annual meeting, as in prior years, will be conducted in a virtual-only format, solely by means of a live audio webcast. Our virtual stockholder format uses technology designed to provide our stockholders rights and opportunities to participate in the virtual meeting similar to an in-person meeting. A virtual meeting allows more stockholders to attend the meeting without cost from anywhere around the globe. You may attend the meeting, vote and submit questions electronically during the meeting via live webcast by visiting the website provided above. A list of stockholders of record will be available electronically during the meeting. The website can be accessed on a computer, tablet, or phone with internet connection. To be admitted to the meeting atwww.virtualshareholdermeeting.com/IRWD2026, you must enter the 16-digit control number found on your proxy card, voting instruction form or notice that you received.

Proxy Material Mailing Date:

April 28, 2026

Sincerely,

Thomas McCourt

Chief Executive Officer and Director

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