CAPRICOR THERAPEUTICS, INC.

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures designed to ensure that information required to be disclosed in our reports under the Securities Exchange Act of 1934, as amended, is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms and that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

As required by Rule 13a-15(b) under the Exchange Act, management, including our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures as of December 31, 2025. Based on that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective as of December 31, 2025.

Management’s Report on Internal Control over Financial Reporting

Management is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act. Our internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements in accordance with U.S. generally accepted accounting principles.

Our internal control over financial reporting includes policies and procedures that are intended to:

Management assessed the effectiveness of our internal control over financial reporting as of December 31, 2025 using the criteria set forth in the Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (“COSO”).

Based on this assessment, management concluded that our internal control over financial reporting was effective as of December 31, 2025.

Attestation Report

This Annual Report on Form 10-K does not include an attestation report of our registered public accounting firm regarding internal control over financial reporting because we are a smaller reporting company, and such attestation is not required pursuant to Section 404(b) of the Sarbanes-Oxley Act.

Changes in Internal Controls over Financial Reporting

During the fiscal year ended December 31, 2025, Capricor implemented changes to its internal control over financial reporting in connection with enhancements to its finance and accounting organization and the implementation of new financial systems, including an enterprise resource planning (“ERP”) system. These changes were part of

management’s ongoing efforts to strengthen the Company’s internal control environment and support its growth and evolving business needs. Management does not believe that these changes have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting.