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CytoDyn Inc.

For the period ended Nov 30, 2025. Filed Jan 9, 2026.

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About this filing

A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.

Nov 30, 2025 · Filed Jan 9, 2026

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ITEM 1. CONSOLIDATED FINANCIAL STATEMENTS

Consolidated Balance Sheets

(Unaudited, in thousands, except par value)

​​​​​​​
​​​November 30, 2025​​ ​ ​May 31, 2025
Assets · ​ · ​ · ​ · ​ · ​
Current assets: · ​ · ​ · ​ · ​
Cash and cash equivalents​$4,982​$11,903
Prepaid expenses​560​252
Prepaid service fees​3,297​3,723
Other receivables​​—​​2,000
Total current assets​8,839​17,878
Other non-current assets​96​169
Total assets​$8,935​$18,047
Liabilities and Stockholders’ Deficit​​​​
Current liabilities:​​​​
Accounts payable​$14,245​$14,692
Accrued liabilities and compensation​19,685​2,206
Accrued interest on convertible notes​14,971​18,151
Accrued dividends on convertible preferred stock​9,011​8,269
Convertible notes payable, net​27,200​27,200
Total current liabilities​85,112​70,518
Other liabilities (Note 10)​​43,571​​43,571
Total liabilities​128,683​114,089
Commitments and Contingencies (Note 10)​​​​
Stockholders’ deficit:​​​​
Preferred stock, $0.001 par value; 5,000 shares authorized:​​​​
Series B convertible preferred stock, $0.001 par value; 400 authorized; 19 issued and outstanding at November 30, 2025 and May 31, 2025​—​—
Series C convertible preferred stock, $0.001 par value; 8 authorized; 6 issued and outstanding at November 30, 2025 and May 31, 2025​—​—
Series D convertible preferred stock, $0.001 par value; 12 authorized; 9 issued and outstanding at November 30, 2025 and May 31, 2025​—​—
Common stock, $0.001 par value; 2,250,000 shares authorized; 1,266,139 and 1,249,460 issued, and 1,265,853 and 1,249,174 outstanding at November 30, 2025 and May 31, 2025, respectively​1,266​1,249
Treasury stock, $0.001 par value; 286 shares at November 30, 2025 and May 31, 2025​​—​​—
Additional paid-in capital​794,919​790,495
Accumulated deficit​(915,933)​(887,786)
Total stockholders’ deficit​(119,748)​(96,042)
Total liabilities and stockholders' deficit​$8,935​$18,047

Consolidated Statements of Operations

(Unaudited, in thousands, except per share data)

​​​​​​​​​​​​​
​ · ​ · Three months ended November 30, · ​ · Six months ended November 30,
​ · ​ ​ ​ · 2025 · ​ ​ ​ · 2024 · ​ ​ ​ · 2025 · ​ ​ ​ · 2024
Operating expenses: · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​
General and administrative​$1,799​$2,298​$3,512​$3,907
Research and development​3,302​1,409​6,534​(22,637)
Legal settlement loss​​16,587​​—​​16,587​​—
Total operating expenses​21,688​3,707​26,633​(18,730)
Operating (loss) gain​(21,688)​(3,707)​(26,633)​18,730
Interest and other income (expense):​​​​​​​​​​​​
Interest income​​57​​142​​151​​268
Interest on convertible notes​(644)​(1,161)​(1,320)​(2,326)
Amortization of discount on convertible notes​​—​​(113)​​—​​(238)
Standby equity purchase agreement commitment fee​(325)​—​(325)​—
Loss on induced conversion​—​​—​​—​​(1,180)
Finance charges​(7)​(9)​(20)​(23)
Gain on restructuring of payables​​—​​80​​—​​80
Loss on derivatives​​—​​—​​—​​(852)
Total interest and other expenses​(919)​(1,061)​(1,514)​(4,271)
(Loss) gain before income taxes​(22,607)​(4,768)​(28,147)​14,459
Income tax benefit​—​—​—​—
Net (loss) income​$(22,607)​$(4,768)​$(28,147)​$14,459
​​​​​​​​​​​​​
(Loss) income per share:​​​​​​​​​​​​
Basic​$(0.02)​$(0.00)​$(0.02)​$0.01
Diluted​$(0.02)​$(0.00)​$(0.02)​$0.01
​​​​​​​​​​​​​
Weighted average common shares used in calculation of (loss) income per share:​​​​​​​​​​​​
Basic​​1,261,016​​1,221,405​​1,256,761​​1,177,988
Diluted​​1,261,016​​1,221,405​​1,256,761​​1,204,193

Consolidated Statement of Changes in Stockholders’ Deficit

(Unaudited, in thousands)

​​​​​​​​​​​​​​​​​​​​​​​​​
​ · ​ · Preferred stock · ​ · Common stock · ​ · Treasury stock · ​ ​ ​ · Additional · ​ ​ ​ · Accumulated · ​ ​ ​ · Total stockholders'
​ · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ · paid-in capital · ​ · deficit · ​ · deficit
Balance at May 31, 2025​34​$—​1,249,460​$1,249​286​$—​$790,495​$(887,786)​$(96,042)
Issuance of stock for convertible note repayment​—​​—​7,462​​8​—​​—​2,242​—​2,250
Stock option exercises​—​​—​100​​—​—​​—​21​—​21
Warrant exercises​—​​—​23​​—​—​​—​—​—​—
Dividends accrued on Series C and D convertible preferred stock​—​​—​—​​—​—​​—​(373)​—​(373)
Stock-based compensation​—​​—​—​​—​—​​—​179​—​179
Net loss​—​​—​—​​—​—​​—​—​(5,540)​(5,540)
Balance at August 31, 2025​34​$—​1,257,045​$1,257​286​$—​$792,564​$(893,326)​$(99,505)
Issuance of stock for convertible note repayment​—​​—​8,060​​8​—​​—​​2,242​​—​2,250
Warrant exercises​—​​—​399​​—​—​​—​​—​​—​​—
Standby equity purchase agreement commitment fee​—​​—​635​​1​—​​—​​299​​—​​300
Dividends accrued on Series C and D convertible preferred stock​—​​—​—​​—​—​​—​​(369)​​—​(369)
Stock-based compensation​—​​—​—​​—​—​​—​​183​​—​183
Net loss​—​​—​—​​—​—​​—​​—​​(22,607)​(22,607)
Balance at November 30, 2025​34​​—​1,266,139​​1,266​286​​—​​794,919​​(915,933)​​(119,748)
​​​​​​​​​​​​​​​​​​​​​​​​​
​ · ​ · Preferred stock · ​ · Common stock · ​ · Treasury stock · ​ ​ ​ · Additional · ​ ​ ​ · Accumulated · ​ ​ ​ · Total stockholders'
​ · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ ​ ​ · Shares · ​ ​ ​ · Amount · ​ · paid-in capital · ​ · deficit · ​ · deficit
Balance at May 31, 2024​34​$—​1,059,002​$1,059​443​$—​$773,714​$(891,531)​$(116,758)
Issuance of stock for convertible note repayment​—​​—​8,777​​9​—​​—​991​—​1,000
Loss on induced conversion​—​​—​—​​—​—​​—​1,180​—​1,180
Stock issued for tender offer​—​​—​152,505​​152​—​​—​13,874​—​14,026
Issuance costs related to stock issued for tender offer​—​​—​—​​—​—​​—​(3,649)​—​(3,649)
Dividends accrued on Series C and D convertible preferred stock​—​​—​—​​—​—​​—​(372)​—​(372)
Stock-based compensation​—​​—​—​​—​—​​—​​136​​—​​136
Net income​—​​—​—​​—​—​​—​—​19,227​19,227
Balance at August 31, 2024​34​$—​1,220,284​$1,220​443​$—​$785,874​$(872,304)​$(85,210)
Issuance of stock for convertible note repayment​—​—​3,233​4​—​—​416​—​420
Dividends accrued on Series C and D convertible preferred stock​—​—​—​—​—​—​(369)​—​(369)
Stock-based compensation​—​—​—​—​—​—​537​—​537
Net loss​—​—​—​—​—​—​—​(4,768)​(4,768)
Balance at November 30, 2024​34​​—​1,223,517​​1,224​443​​—​​786,458​​(877,072)​​(89,390)

Consolidated Statements of Cash Flows

(Unaudited, in thousands)

​​​​​​​
​ · ​ · Six months ended November 30,
​ · ​ ​ ​ · 2025 · ​ ​ ​ · 2024
​​​​​​​
Cash flows from operating activities: · ​ · ​ · ​ · ​
Net (loss) income​$(28,147)​$14,459
Adjustments to reconcile net (loss) income to net cash used in operating activities:​​​​
Depreciation​9​9
Standby equity purchase agreement non-cash commitment fee​300​—
Amortization of discount on convertible notes​—​238
Gain on restructuring of payables​​—​​(80)
Loss on derivatives​​—​​852
Loss on induced conversion​​—​​1,180
Stock-based compensation​362​673
Changes in operating assets and liabilities:​​​​
Prepaid expenses and other assets​​2,182​​(2,229)
Accounts payable, accrued expenses, and other liabilities​18,494​(13,248)
Net cash (used in) provided by operating activities​(6,800)​1,854
Cash flows from investing activities:​​​​
Net cash provided by/used in investing activities​—​—
Cash flows from financing activities:​​​​
Proceeds from warrant transactions, net of offering costs​​—​​10,377
Proceeds from exercise of stock options​21​—
Cash paid for note payable​​(142)​​(710)
Net cash (used in) provided by financing activities​(121)​9,667
Net change in cash and cash equivalents​(6,921)​11,521
Cash and cash equivalents at beginning of period​11,903​9,814
Cash and cash equivalents at end of period​$4,982​$21,335
Supplemental disclosure:​​​​​​
Cash paid for interest​$20​$23
Non-cash investing and financing transactions:​​​​
Issuance of common stock for interest on convertible notes​$4,500​$1,420
Accrued dividends on Series C and D convertible preferred stock​$742​$741

CYTODYN INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

AS OF NOVEMBER 30, 2025

(Unaudited)

Note 1. Organization

CytoDyn Inc. (together with its wholly owned subsidiary, the “Company”) was originally incorporated under the laws of Colorado on May 2, 2002, under the name RexRay Corporation and, effective August 27, 2015, reincorporated under the laws of Delaware. The Company is a clinical-stage biotechnology company focused on the clinical development of innovative treatments for multiple therapeutic indications based on its product candidate, leronlimab, a novel humanized monoclonal antibody targeting the C-C chemokine receptor type 5 (“CCR5”).

The Company investigates leronlimab as a viral entry inhibitor believed to competitively bind to the N-terminus and second extracellular loop of the CCR5 receptor. The CCR5 receptor is believed to be implicated in immune-mediated illnesses. Leronlimab is being studied in solid tumors in oncology. The Company also strategically works with select partners to explore leronlimab’s potential benefits in certain inflammatory diseases.

Note 2. Summary of Significant Accounting Policies

Basis of presentation

The unaudited consolidated financial statements include the accounts of CytoDyn Inc. and its wholly owned subsidiary, CytoDyn Operations Inc. All intercompany transactions and balances are eliminated in consolidation. The consolidated financial statements reflect all normal recurring adjustments which are, in the opinion of management, necessary for a fair statement of the results of operations for the interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States(“U.S. GAAP” or “GAAP”)have been omitted in accordance with the rules and regulations of the United States Securities and Exchange Commission (“SEC”). The interim financial information and notes thereto should be read in conjunction with the Company's latest Annual Report on Form 10-K for the fiscal year ended May 31, 2025 (the “2025 Form 10-K”). The results of operations for the periods presented are not necessarily indicative of results to be expected for the entire fiscal year or for any other future annual or interim period.

Going concern

The accompanying consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. As presented in the accompanying consolidated financial statements, the Company had losses for all periods presented, except for the six months ended November 30, 2024 due to a one-time return of clinical expenses. The Company has an accumulated deficit of approximately $915.9 million as of November 30, 2025. These factors, among others, including the various matters discussed in Note 10,Commitments and Contingencies, raise substantial doubt about the Company’s ability to continue as a going concern. The consolidated financial statements do not include any adjustments relating to the recoverability of assets and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

The Company’s continuance as a going concern is dependent upon its ability to obtain additional operating capital, complete the development of its product candidate, leronlimab, obtain approval to commercialize leronlimab from regulatory agencies, continue to outsource manufacturing of leronlimab, and ultimately generate revenues and attain profitability. The Company plans to continue to engage in research and development activities related to leronlimab and a new or modified longer-acting therapeutic for multiple indications and expects to incur significant research and development expenses in the future, primarily related to its regulatory compliance, including performing additional pre-clinical and clinical studies in various indications, and seeking regulatory approval for its product candidate for commercialization. These research and development activities are subject to significant risks and uncertainties. The Company intends to finance its future development activities and its working capital needs primarily from the sale of

equity and debt securities, combined with additional funding from other sources. However, there can be no assurance that the Company will be successful in these endeavors.

Use of estimates

The unaudited consolidated financial statements have been prepared in accordance with GAAP, which requires management to make estimates and judgments that affect the reported amounts of assets, liabilities, and the disclosure of contingent assets and liabilities at the date of consolidated financial statements, and the reported amounts of expenses during the reporting period. Estimates are assessed each period and updated to reflect current information, such as the status of our analysis of the results of our clinical trials and discussions with the U.S. Food and Drug Administration (“FDA”), which could have an impact on the Company’s significant accounting estimates and assumptions. The Company’s estimates are based on historical experience and on various other assumptions that are believed to be reasonable under the circumstances. Significant estimates include, but are not limited to, those relating to stock-based compensation. Actual results could differ from these estimates.

Cash and cash equivalents

Cash and cash equivalents are short-term, highly liquid investments with original maturities of three months or less when purchased and comprise bank deposits, money market funds, and treasury bills with original maturity dates of three months or less. Our investments in money market funds and treasury bills are recorded at fair value. The following table summarizes, by major security type, our cash and cash equivalents:

​​​​​​​
​ · ​ · November 30, 2025
​​Cost or​Gross​Total
​​amortized​unrealized​estimated
(in thousands)​cost​gains​fair value
Cash$1,286$—$1,286
Level 1 securities:​​​​​​
Money market funds​680​—​680
U.S. treasuries$3,016$—$3,016
​​​​​​​
​ · ​ · May 31, 2025
​​Cost or​Gross​Total
​​amortized​unrealized​estimated
(in thousands)​cost​gains​fair value
Cash$534$—$534
Level 1 securities:​​​​​​
Money market funds$11,369$—$11,369

Fair value of financial instruments

In accordance with the prescribed accounting guidance, the Company measured fair value of money market funds, treasury bills, and common shares related to the Securities Class Action Lawsuits settlement using the fair value hierarchy which include:

Level 1. Quoted prices in active markets for identical assets or liabilities.

Level 2.Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities, quoted prices in markets with insufficient volume or infrequent transactions (less active markets), or model-derived valuations in which all significant inputs are observable or can be derived principally from or corroborated with observable market data for substantially the full term of the assets or

liabilities. Level 2 inputs also include non-binding market consensus prices that can be corroborated with observable market data, as well as quoted prices that were adjusted for security-specific restrictions.

Level 3.Unobservable inputs to the valuation methodology are significant to the measurement of the fair value of assets or liabilities. These Level 3 inputs also include non-binding market consensus prices or non-binding broker quotes that the Company was unable to corroborate with observable market data.

Recent Accounting Pronouncements

In October 2023, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2023-06,Disclosure Improvements–*Codification Amendments in Response to the SEC’s Disclosure Update and Simplification Initiative.*The amendments clarify or improve disclosure and presentation requirements on various disclosure areas, including the statement of cash flows, earnings per share, debt, equity, and derivatives. The amendments will align the requirements in the FASB Accounting Standards Codification (“ASC”) with the SEC’s regulations. The amendments in this ASU will be effective on the date the related disclosures are removed from Regulation S-X or Regulation S-K by the SEC and will not be effective if the SEC has not removed the applicable disclosure requirement by June 30, 2027. Early adoption is prohibited. The Company is currently evaluating the potential impact of this update on its financial statement disclosures.

In December 2023, the FASB issued ASU No. 2023-09,Improvements to Income Tax Disclosures, which requires disclosure of disaggregated income taxes paid, prescribes standard categories for the components of the effective tax rate reconciliation, and modifies other income tax-related disclosures. The ASU is effective for annual periods beginning after December 15, 2024, and allows for adoption on a prospective basis, with a retrospective option. The Company is currently evaluating the potential impact of this update on its consolidated financial statements and related disclosures.

In November 2024, the FASB issued ASU 2024-03,“Income Statement (Topic 220): Reporting Comprehensive Income - Expense Disaggregation Disclosures, Disaggregation of Income Statement Expenses," which requires public companies to disclose, in interim and annual reporting periods, additional information about certain expenses in the financial statements. In January 2025, the FASB issued ASU 2025-01, “Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40) – Clarifying the Effective Date” to clarify the effective date for non-calendar year-end entities. The amendments in this ASU will be effective for annual periods beginning after December 15, 2026, and interim reporting periods within annual reporting periods beginning after December 15, 2027. Early adoption is permitted and is effective on either a prospective basis or retrospective basis. The Company is currently evaluating the potential impact of this update on its consolidated financial statements and related disclosures.

In November 2024, the FASB issued ASU 2024-04,"Debt—Debt with Conversion and Other Options (Subtopic 470-20): Induced Conversions of Convertible Debt Instruments," which clarifies the requirements for determining whether certain settlements of convertible debt instruments should be accounted for as an induced conversion or extinguishment of convertible debt. The new guidance is effective for annual reporting periods beginning after December 15, 2025, and interim periods within those annual periods. The Company is currently evaluating the potential impact of this update on its consolidated financial statements and related disclosures.

Note 3. Accrued Liabilities and Compensation

The components of accrued liabilities and compensation are as follows (in thousands):

​​​​​​​
​​​November 30, 2025​​May 31, 2025
Compensation and related expense​$266​$278
Legal settlement​​16,587​​—
Legal fees​​10​​50
Clinical expense​​1,372​​487
License fees​​1,375​​1,105
Lease payable​​69​​141
Other liabilities​​6​​145
Total accrued liabilities​$19,685​$2,206

Note 4. Convertible Instruments and Accrued Interest

Convertible preferred stock

The following table presents the number of potentially issuable shares of common stock, should shares of preferred stock and amounts of undeclared and accrued preferred dividends be converted to common stock.* *

​​​​​​​​​​​​​​​​​​​
​ · ​ · November 30, 2025 · ​ · May 31, 2025
(in thousands except conversion rate) · ​ ​ ​ · Series B · ​ ​ ​ · Series C · ​ ​ ​ · Series D · ​ ​ ​ · Series B · ​ ​ ​ · Series C · ​ ​ ​ · Series D
Shares of preferred stock outstanding​​19​​6​​9​​19​​6​​9
Common stock conversion rate​​10:1​​2,000:1​​1,250:1​​10:1​​2,000:1​​1,250:1
Total shares of common stock if converted​​190​​12,670​​10,565​​190​​12,670​​10,565
Undeclared dividends​$27​$—​$—​$24​$—​$—
Accrued dividends​$—​$4,087​$4,924​$—​$3,769​$4,500
Total shares of common stock if dividends converted​​54​​8,174​​9,848​​48​​7,538​​9,000

Under the Company’s Amended and Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”), dividends on its outstanding shares of Series B Convertible Preferred Stock (the “Series B preferred stock”) may be paid in cash or shares of the Company’s common stock at the election of the Company. Dividends on outstanding shares of Series C Convertible Preferred Stock (the “Series C preferred stock”) and Series D Convertible Preferred Stock (the “Series D preferred stock”) are payable in cash or shares of common stock at the election of the holder. The preferred stockholders have the right to dividends only when and if declared by the Company’s Board of Directors. Under Section 170 of the Delaware General Corporation Law, the Company is permitted to pay dividends only out of capital surplus or, if none, out of net profits for the fiscal year in which the dividend is declared or net profits from the preceding fiscal year.

Series B preferred stock provides for a liquidation preference over the common shares of $5.00 per share, plus any accrued and unpaid dividends. In the event of liquidation, holders of Series C and Series D preferred stock will be entitled to receive, on a pari passu basis, and in preference of any payment or distribution to holders of the Series B preferred stock and common stock, an amount per share equal to $1,000 per share plus any accrued and unpaid dividends.

Convertible Notes and Accrued Interest

The table below presents outstanding convertible notes and accrued interest as of November 30, 2025 and May 31, 2025:

​​​​​​​​​​​​​​​​​​​
​ · ​ · November 30, 2025 · ​ · May 31, 2025
(in thousands) · ​ ​ ​ · April 2, 2021 Note · ​ ​ ​ · April 23, 2021 Note · ​ ​ ​ · Total · ​ ​ ​ · April 2, 2021 Note · ​ ​ ​ · April 23, 2021 Note · ​ · Total
Convertible notes payable outstanding principal​$2,831​$24,369​$27,200​$2,831​$24,369​$27,200
Accrued interest on convertible notes​​5,629​​9,342​​14,971​​5,378​​12,773​​18,151
Outstanding convertible notes payable, net and accrued interest​$8,460​$33,711​$42,171​$8,209​$37,142​$45,351

Reconciliation of changes to the outstanding balance of convertible notes, including accrued interest, were as follows:

​​​​​​​​​​
(in thousands) · ​ · April 2, 2021 Note · ​ · April 23, 2021 Note · ​ · Total
Outstanding balance at May 31, 2025​$8,209​$37,142​$45,351
Interest expense​​251​​1,069​​1,320
Fair market value of shares exchanged for repayment​​—​​(4,500)​​(4,500)
Outstanding balance at November 30, 2025​$8,460​$33,711​$42,171

April 2, 2021 & April 23, 2021 Notes

Key terms of the outstanding convertible notes (the “Notes”) are as follows:

​​​​​​​​​
​ · ​ · November 30, 2025
​ · ​ ​ ​ · April 2, 2021 Note · ​ ​ ​ · ​ · April 23, 2021 Note · ​
Interest rate per annum​​6%​​6%
Conversion price per share upon five trading days' notice​$10.00​​$10.00​
Party that controls the conversion rights​​Investor​​​Investor​
Maturity date​​April 5, 2026​​​April 23, 2026​
Security interest​​All Company assets excluding intellectual property​

In addition to standard anti-dilution adjustments, the conversion price of the Notes is subject to full-ratchet anti-dilution protection, pursuant to which the conversion price will be automatically reduced to equal the effective price per share in any new offering by the Company of equity securities that have registration rights, are registered, or become registered under the Securities Act of 1933, as amended (the “Securities Act”). The Notes provide for liquidated damages upon failure to deliver common stock within specified timeframes and require the Company to maintain a share reservation of 6.0 million shares of common stock for each Note.

During the six months ended November 30, 2025, in satisfaction of the required monthly payments, the Company and April 23, 2021 Noteholder entered into exchange agreements, pursuant to which the April 23, 2021 Note was partitioned into new notes (the “Partitioned Notes”) with an aggregate principal amount of approximately $4.5 million, which was exchanged concurrently with the issuance of shares of common stock of equal value, amounting to approximately 15.5 million shares of common stock. The monthly payments were applied to accrued interest on convertible notes. The outstanding balance of the April 23, 2021 Note was reduced by the Partitioned Notes to a total amount of $33.7 million.

As of the filing date of this report, the holders of the Notes waived all provisions that, based on the occurrence of various events through that date, could have triggered the imposition of a default interest rate, a downward adjustment of the conversion price, or specified other provisions relating to default, breach or imposition of a penalty. Accordingly, the Company was not in default under the Notes on the filing date of this report.

Note 5. Equity

Standby Equity Purchase Agreement

On November 3, 2025, the Company entered into a Standby Equity Purchase Agreement (the “Purchase Agreement”) with YA II PN, Ltd., a Cayman Islands exempt limited partnership (“Yorkville”).

Pursuant to and subject to the terms of the Purchase Agreement, for 36 months following the date of the Purchase Agreement, the Company has the right, but not the obligation, to sell to Yorkville, and Yorkville is obligated to purchase from the Company, shares of the Company’s common stock (“Common Stock”).

At the Company’s option, the shares of Common Stock would be purchased at 98% of the lowest daily volume weighted average price (“VWAP”) during thethree consecutive trading days (the “Pricing Period”) commencing on the date (each, an “Advance Notice Date”) the Company is deemed to have delivered a written notice to Yorkville setting forth the number of shares of Common Stock that the Company desires to issue and sell to Yorkville in accordance with the terms of the Purchase Agreement (each notice, an “Advance Notice”), subject to certain limitations. The Company, at its discretion, may also specify a minimum acceptable price per share in an Advance Notice (each issuance and sale, an “Advance”). While there is no mandatory minimum amount for any Advance, it may not exceed an amount equal to 100% of the average of the daily traded amount on the five consecutive trading days immediately preceding an Advance Notice. Further, subject to the above conditions, in no event shall Yorkville be required to purchase more than $30,000,000 of shares of Common Stock in the aggregate during the term of the Purchase Agreement (the “Commitment Amount”).

As consideration for Yorkville’s commitment to purchase the shares of Common Stock pursuant the Purchase Agreement, the Company (i) paid Yorkville a structuring fee in the amount of $25,000; and (ii) will pay a commitment fee in an amount equal to 1.00% of the Commitment Amount (the “Commitment Fee”), to be paid in the form of shares of Common Stock issued to Yorkville (the “Commitment Shares”), of whichone-half was issued on November 3, 2025, and the remainingone-half shall be issued on the six-month anniversary of the Purchase Agreement.

The Purchase Agreement will automatically terminate on the earlier of (i) the 36-month anniversary of the date of the Purchase Agreement, or (ii) the date Yorkville has made full payment of Advances equal to the Commitment Amount. The Company has the right to terminate the Purchase Agreement upon five trading days’ prior written notice to Yorkville, subject to certain conditions. The Company and Yorkville may also agree to terminate the Purchase Agreement by mutual written consent.

Warrants

Warrant activity is presented in the table below:

​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​
​ · ​ · ​ · ​ · ​ · ​ · ​ · Weighted · ​ · ​ · ​
​ · ​ · ​ · ​ · ​ · ​ · ​ · average · ​ · ​ · ​
​ · ​ · ​ · ​ · Weighted · ​ · remaining · ​ · Aggregate
​ · ​ · Number of · ​ · average · ​ · contractual · ​ · intrinsic
(in thousands, except for share data and years) · ​ ​ ​ · shares · ​ ​ ​ · exercise price · ​ ​ ​ · life in years · ​ ​ ​ · value
Warrants outstanding at May 31, 2025213,128​$0.273.71​$27,923
Granted—​$—​​​
Exercised(597)​$0.09​​129
Forfeited, expired, and cancelled(105)​$3.07​​​
Warrants outstanding at November 30, 2025212,426​$0.263.20​$23,593
Warrants outstanding and exercisable at November 30, 2025212,426​$0.263.20​$23,593

Warrant exercises

During the six months ended November 30, 2025, the Company issued approximately 0.4 million shares of common stock in connection with the cashless exercise of approximately 0.6 million warrants with stated exercise prices of $0.09387 per share.

Note 6. Equity Incentive Plan

Equity Incentive Plan

As of November 30, 2025, the Company hadone active equity incentive plan, theCytoDyn Inc. Amended and Restated 2012 Equity Incentive Plan (the “EIP”). As of November 30, 2025 and May 31, 2025, the EIP covered a total of 79.3 million and 66.8 million shares of common stock, respectively. The “evergreen provision” automatically increased the number of shares of common stock subject to the EIP by an amount equal to 1% of the total outstanding shares on June 1, 2025. The EIP provides for awards of stock options to purchase shares of common stock, restricted and unrestricted shares of common stock, restricted stock units (“RSUs”), and performance share units (“PSUs”).

The Company recognizes the compensation cost of employee and director services received in exchange for equity awards based on the grant date estimated fair value of the awards. Share-based compensation cost is recognized over the period during which the employee or director is required to provide services in exchange for the award and, as forfeitures occur, the associated compensation cost recognized to date is reversed. For awards with performance-based payout conditions, the Company recognizes compensation cost based on the probability of achieving the performance conditions, with changes in expectations recognized as an adjustment to earnings in the period of change. Any recognized compensation cost is reversed if the conditions ultimately are not met.

Stock-based compensation for the three months ended November 30, 2025 and 2024 was approximately $0.2 million and $0.5 million, respectively, and for the six months ended November 30, 2025 and 2024 was $0.4 million and $0.7 million, respectively. Stock-based compensation is recorded in general and administrative and research and development costs.

Stock options

Stock option activity is presented in the table below:

​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​
​ · ​ · ​ · ​ · ​ · ​ · ​ · Weighted · ​ · ​ · ​
​ · ​ · ​ · ​ · ​ · ​ · ​ · average · ​ · ​ · ​
​ · ​ · ​ · ​ · Weighted · ​ · remaining · ​ · Aggregate
​ · ​ · Number of · ​ · average · ​ · contractual · ​ · intrinsic
(in thousands, except per share data and years) · ​ ​ ​ · shares · ​ ​ ​ · exercise price · ​ ​ ​ · life in years · ​ ​ ​ · value
Options outstanding at May 31, 202538,324​$0.467.65​$4,039
Granted725​$0.30​​​
Exercised(100)​$0.21​​6
Forfeited, expired, and cancelled(480)​$1.93​​​
Options outstanding at November 30, 202538,469​$0.447.26​$3,791
Options outstanding and exercisable at November 30, 202530,700​$0.456.82​$2,717

During the six months ended November 30, 2025 and 2024, stock options for approximately 0.7 million shares and 11.7 million shares, respectively, were granted. Of the options granted in the current year, approximately 0.4 million vest over four years, and approximately 0.3 million vest overone year. Of the options granted in the prior year, approximately 5.7 million vest over four years, and approximately 6.0 million vest overone year. The Company records compensation expense based on the Black-Scholes fair value per share of the awards on the grant date. The weighted average fair value per share was $0.26 and $0.12 for the stock options granted in the six months ended November 30, 2025 and 2024, respectively.

PSUs

The following table summarizes the Company’s PSU activity:

​​​​​​​​
​​​​​​​Weighted average
​ · ​ · Number of · ​ · Weighted average · ​ · remaining contractual
(shares in thousands) · ​ ​ ​ · RSUs and PSUs (1) · ​ ​ ​ · grant date fair value · ​ · life in years
Unvested PSUs at May 31, 2025​3,500​​0.41​1.75
PSUs granted​—​​​​​
PSUs forfeited​—​​​​​
PSUs vested​—​​​​​
Unvested PSUs at November 30, 20253,500​$0.41​1.25
(1)The number of PSUs disclosed in this table are at the target level of 100%.

The vesting of the PSUs is subject to the achievement of specified performance-based conditions, and the actual number of common shares that will ultimately be issued will be determined by multiplying this number of PSUs by a payout percentage ranging from 0% to 100%.

Based on the estimated level of achievement of the performance targets associated with the PSUs as of November 30, 2025, unrecognized compensation expense related to the unvested portion of the Company’s PSUs was$1.4 million, which is expected to be recognized over a weighted-average period of 1.3 years.

Note 7. (Loss) Income per Share

Basic (loss) income per share is computed by dividing the net (loss) income adjusted for preferred stock dividends by the weighted average number of common shares outstanding during the period. Diluted (loss) income per share includes the weighted average common shares outstanding and potentially dilutive common stock equivalents. Basic and diluted (loss) income per share for the three and six months ended November 30, 2025 and 2024 were calculated as follows:

​​​​​​​​​​​​​
​ · ​ · Three months ended November 30, · ​ · Six months ended November 30,
(in thousands, except per share amounts) · ​ · 2025 · ​ ​ ​ · 2024 · ​ · 2025 · ​ · 2024
Numerator:​​​​​​​​​​​​
Net (loss) income​$(22,607)​$(4,768)​$(28,147)​$14,459
Less: Accrued preferred stock dividends​​(369)​​(369)​​(742)​​(741)
Basic net (loss) income applicable to common stockholders​​(22,976)​​(5,137)​​(28,889)​​13,718
Diluted net (loss) income applicable to common stockholders​$(22,976)​$(5,137)​$(28,889)​$13,718
​​​​​​​​​​​​​
Denominator:​​​​​​​​​​​​
Basic weighted average common shares outstanding​​1,261,016​​1,221,405​​1,256,761​​1,177,988
Effect of dilutive securities:​​​​​​​​​​​​
Warrant exercises​​—​​—​​—​​26,205
Diluted weighted average common shares outstanding​​1,261,016​​1,221,405​​1,256,761​​1,204,193
​​​​​​​​​​​​​
Basic (loss) income per share​$(0.02)​$(0.00)​$(0.02)​$0.01
Diluted (loss) income per share​$(0.02)​$(0.00)​$(0.02)​$0.01

The table below shows the approximate number of shares of common stock issuable upon the exercise, vesting, or conversion of outstanding options, PSUs, warrants, convertible notes, and convertible preferred stock (including

undeclared dividends) that were not included in the computation of diluted weighted average number of shares of common stock outstanding for the periods presented:

​​​​​
​ · Three and six months ended November 30, · ​
(in thousands)2025​ ​ ​2024​
Stock options, PSUs, and warrants254,395​240,898​
Convertible notes12,000​12,000​
Convertible preferred stock41,500​38,533​

Note 8. Income Taxes

To determine the Company’s quarterly provision for income taxes, the Company used an estimated annual effective tax rate that is based on expected annual income and statutory tax rates in the various jurisdictions in which the Company operates. Certain significant unusual or infrequently occurring items that are separately reported are separately recognized in the quarter during which they occur and can be a source of variability in the effective tax rate from quarter to quarter.

The Company hadno income tax expense for the three and six months ended November 30, 2025 and 2024. The provision for income taxes for the three and six months ended November 30, 2025 and 2024 is based on the Company’s estimated annualized effective tax rate for the fiscal years ending May 31, 2026 and 2025, respectively. For the three and six months ended November 30, 2025, the Company’s recognized effective tax rate differs from the U.S. federal statutory rate due to the Company maintaining a full valuation allowance on its net deferred tax assets, as the Company does not consider it more likely than not that the benefits from the net deferred tax assets will be realized.

Note 9. Fair Value Measurement

The following table provides information by level for assets and liabilities that are measured at fair value on a recurring basis.

​​​​​​​
(in thousands)​November 30, 2025​May 31, 2025​level
Assets:​​​​​​
Cash$1,286$534​Level 1
Money market funds​680​11,369​Level 1
U.S. treasuries​3,016​—​Level 1
​​​​​​​
Liabilities:​​​​​​
Common stock$(16,087)$—​Level 1

Our investments in money market funds, U.S. treasuries, and common stock are classified within Level 1 of the fair value hierarchy because they are valued using quoted market prices.

Note 10. Commitments and Contingencies

Other Liabilities

The $43.6 million balance recorded in other liabilities is conditional, and will only be due and payable, upon the Company achieving a qualifying “Revenue” event, as defined below. The Company has agreed to pay 20% of its qualifying Revenue generated in each calendar year, if any, with such payments to be applied to reduce the balance until it is repaid in full. Interest will not accrue on the balance throughout the prospective repayment period. Revenue is defined as:

“…the gross revenue generated by Client and its Affiliates, less the following items (if not previously deducted from the amount invoiced): (a) reasonable and customary trade, quantity, and cash discounts actually granted and legally permitted wholesaler chargebacks actually paid or credited by Client and its Affiliates to

wholesalers of products; (b) reasonable, customary, and legally permitted rebates and retroactive price reductions actually granted; (c) freight charges for the delivery of products; (d) the portion of the administrative fees paid during the relevant time period to group purchasing organizations, pharmaceutical benefit managers and/or government-mandated Medicare or Medicaid Prescription Drug Plans relating specifically to the product; and (e) sales, use or excise taxes imposed and actually paid in connection with the sale of products (but excluding any value added taxes or taxes based on income or gross receipts).”

Operating lease commitments

The Company leases its principal office location in Vancouver, Washington (the “Vancouver Lease”). The Vancouver Lease expires on April 30, 2026. Consistent with the guidance in ASC 842, Leases, the Company has recorded this lease in its consolidated balance sheet as an operating lease. For the purpose of determining the right of use asset and associated lease liability, we determined that the renewal of the Vancouver lease was not reasonably probable. The lease does not include any restrictions or covenants requiring special treatment under ASC 842, Leases. Operating lease costs for the three months ended November 30, 2025 and 2024 were approximately$31.0 thousand and$32.0 thousand, respectively, and for the six months ended November 30, 2025 and 2024 were approximately$0.1 million. Operating lease right-of-use assets are included in other non-current assets and the current portion of operating lease liabilities are included in accrued liabilities and compensation on the consolidated balance sheets. The following table summarizes the operating lease balances:

​​​​​​​​
​ · ​ · ​ · ​
(in thousands)​​November 30, 2025​​May 31, 2025​
Assets​​​​​​​
Right-of-use asset​$65​$130​
Liabilities​​​​​​​
Current operating lease liability​$69​$141​
Non-current operating lease liability​—​—​
Total operating lease liability​$69​$141​

The minimum (base rental) lease payments are expected to be as follows as of November 30, 2025 (in thousands):

​​​​
Fiscal Year · ​ · Amount
2026 - 6 months remaining​$77
Thereafter​​—
Total operating lease payments​​77
Less: imputed interest​​(8)
Present value of operating lease liabilities​$69

Supplemental information related to operating leases was as follows:

​​​​
​ · ​ · November 30, 2025
Weighted average remaining lease term​0.4years
Weighted average discount rate​10.0%

PRO 140 Acquisition and Licensing Arrangements

Refer to Note 9,Commitments and Contingencies, in the 2025 Form 10-K for additional information.

Legal proceedings

As of November 30, 2025, the Company recorded an accrual of $16.6 million related to the Securities Class Action Lawsuit described below. The Company did not record any other accruals related to the outcomes of the legal matters described below. It is not possible to determine the outcome of these proceedings, including the defense and other litigation-related costs and expenses that may be incurred by the Company, as the outcomes of legal proceedings are inherently uncertain. Therefore, it is possible that the ultimate outcome of any proceeding, if in excess of a recognized accrual, if any, could be material to the Company’s consolidated financial statements.

Conclusion of Investigations by Securities and Exchange Commission and Department of Justice

In September 2025, the Securities and Exchange Commission (“SEC”) and Department of Justice (“DOJ”) informed the Company that their respective investigations were effectively closed, and that nothing further was required of the Company.

Securities Class Action Lawsuits

On March 17, 2021, a stockholder filed a putative class-action lawsuit (the “March 17, 2021 lawsuit”) in the U.S. District Court for the Western District of Washington against the Company and certain former officers. The complaint generally alleges the defendants made false and misleading statements regarding the viability of leronlimab as a potential treatment for COVID-19. On April 9, 2021, a second stockholder filed a similar putative class action lawsuit in the same court, which the plaintiff voluntarily dismissed without prejudice on July 23, 2021. On August 9, 2021, the court appointed lead plaintiffs for the March 17, 2021 lawsuit. On December 21, 2021, lead plaintiffs filed an amended complaint, which is brought on behalf of an alleged class of those who purchased the Company’s common stock between March 27, 2020 and May 17, 2021. The amended complaint generally alleges that the defendants violated Sections 10(b) and/or 20(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and Rule 10b-5 promulgated thereunder by making purportedly false or misleading statements concerning, among other things, the safety and efficacy of leronlimab as a potential treatment for COVID-19, the Company’s CD10 and CD12 clinical trials, and its human immunodeficiency virus (“HIV”) Biologic License Application (“BLA”). The amended complaint also alleges that the individual defendants violated Section 20A of the Exchange Act by selling shares of the Company’s common stock purportedly while in possession of material nonpublic information. The amended complaint seeks, among other relief, a ruling that the case may proceed as a class action and unspecified damages and attorneys’ fees and costs. On February 25, 2022, the defendants filed a motion to dismiss the amended complaint. On June 24, 2022, lead plaintiffs filed a second amended complaint. The second amended complaint is brought on behalf of an alleged class of those who purchased the Company’s common stock between March 27, 2020 and March 30, 2022, makes similar allegations, names the same defendants, and asserts the same claims as the prior complaint, adds a claim for alleged violation of Section 10(b) of the Exchange Act and Rule 10b-5(a) and (c) promulgated thereunder, and seeks the same relief as the prior complaint. All defendants filed motions to dismiss the second amended complaint in whole or in part. By order dated June 25, 2025, the court denied defendants’ motions to dismiss.

On November 23, 2025, the Company reached an agreement in principle to settle the putative class-action lawsuit. The agreement in principle provides for a payment by the Company to the class of $500,000 in cash and 49 million shares of common stock of the Company in exchange for the dismissal and release of all claims against all defendants in the class action. The agreement is subject to final documentation, court approval, and other conditions.

There can be no assurances as to the ultimate outcome of the class action, including that the final settlement agreement will be executed, that the settlement agreement, if executed, will include the terms and conditions currently anticipated by the Company, that such agreement will be approved by the court, or that any revised settlement terms, if applicable, will be finalized by the parties and approved by the court. A final, non-appealable closure of the litigation could take several months. The agreement in principle does not constitute an admission by the Company of any fault or liability and the Company does not admit fault or liability. If the settlement cannot be finalized by the parties or is not approved by the court, the Company will defend the class action vigorously and believes there are meritorious defenses and legal standards that must be met for, among other things, success by the plaintiffs on the merits. If the parties are

unable to finalize the settlement, the class action could have a material adverse effect on the Company’s financial condition, results of operations, and cash flows.

Shareholder Derivative Lawsuits

On June 4, 2021, a stockholder filed a purported derivative lawsuit against certain of the Company’s former officers and directors, and the Company as a nominal defendant, in the U.S. District Court for the Western District of Washington. Two additional shareholder derivative lawsuits were filed against the same defendants in the same court on June 25, 2021 and August 18, 2021, respectively. The court has consolidated these three lawsuits for all purposes (“Consolidated Derivative Suit”). On January 20, 2022, the plaintiffs filed a consolidated complaint. The consolidated complaint generally alleges that the director defendants breached their fiduciary duties by allowing the Company to make false and misleading statements regarding, among other things, the safety and efficacy of leronlimab as a potential treatment for COVID-19, the Company’s CD10 and CD12 clinical trials and its HIV BLA, and by failing to maintain an adequate system of oversight and controls. The consolidated complaint also asserts claims against one or more individual defendants for waste of corporate assets, unjust enrichment, contribution for alleged violations of the federal securities laws, and for breach of fiduciary duty arising from alleged insider trading. The consolidated complaint seeks declaratory and equitable relief, an unspecified amount of damages, and attorneys’ fees and costs.

On January 29, 2024, two purported stockholders filed a purported derivative lawsuit against certain of the Company’s former officers, certain current and former directors, and the Company as a nominal defendant, in the Delaware Court of Chancery. The complaint generally makes allegations similar to those set forth in the Consolidated Derivative Suit and asserts that the individual defendants breached their fiduciary duties by allowing the Company to make false and misleading statements and by failing to maintain an adequate system of oversight and controls. The complaint also asserts claims against certain individual defendants for breach of fiduciary duty arising from alleged insider trading.

On June 20, 2025, two other purported stockholders filed a purported derivative lawsuit against certain of the Company’s former officers, certain former and current directors, a third-party individual, and the Company as a nominal defendant, in the Delaware Court of Chancery. The complaint generally asserts that the individual defendants breached their fiduciary duties by allowing the Company to make false and misleading statements, by failing to maintain an adequate system of oversight and controls, and/or by purportedly wrongfully refusing plaintiffs’ demands that the Company’s board investigate and initiate claims against certain of the Company’s former officers and directors based on allegations and claims similar to those set forth in the complaint. The complaint also asserts claims against certain individual defendants arising from alleged insider trading. The parties have filed a stipulation and proposed order to consolidate this lawsuit with the January 2024 lawsuit.

The Company and the individual defendants deny all allegations of wrongdoing in the complaints and intend to vigorously defend the litigation. In light of the fact that the suit(s) is/are in an early stage and the claims do not specify an amount of damages, the Company cannot predict the ultimate outcome of the matter(s) and cannot reasonably estimate the potential loss or range of loss the Company may incur.

Investor Lawsuit Seeking Issuance of Additional Shares

In January 2025, two former investors and current shareholders filed an action against the Company in relation to a dispute over how many shares were issued to them following their direct investment(s) with the Company. The former investors claim that the final pricing utilized to calculate the issuance of shares to them in 2022 was incorrect, and that they are entitled to more shares than were issued. The complaint presents legal claims sounding in breach of fiduciary duty, misrepresentation, fraud, negligence, theft, and breach of contract.

The Company's position is that the claims are without any factual support, or support under applicable law and/or the underlying investment documents. The Company views this action as an attempt to extract more shares without further/fair investment and plans to vigorously defend itself.

Note 11. Segment Information

The Company’s measure of segment profit or loss is net earnings or loss. The measure ofsegment assets is reported on the consolidated balance sheets as total assets.

The following table is representative of the significant expense categories regularly provided to the CODM when managing the Company’s single reporting segment.

​​​​​​​​​​​​​
​ · ​ · Three months ended November 30, · ​ · Six months ended November 30,
(in thousands, except for per share data) · ​ ​ ​ · 2025 · ​ ​ ​ · 2024 · ​ ​ ​ · 2025 · ​ ​ ​ · 2024
Expenses(1): · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​ · ​
General and administrative expense(2)​$1,706$1,978​$3,329$3,451
Research and development(3)​3,2121,192​6,3552,131
Return of clinical expenses​​—​​—​​—​​(24,985)
Legal settlement loss​​16,587​​—​​16,587​​—
Stock-based compensation expense​​183​​537​​362​​673
Total operating expenses​​21,688​​3,707​​26,633​​(18,730)
Operating (loss) gain​​(21,688)​​(3,707)​​(26,633)​​18,730
​​​​​​​​​​​​​
Interest income​​57​​142​​151​​268
Interest on convertible notes​​(644)​​(1,161)​​(1,320)​​(2,326)
Amortization of discount on convertible notes​​—​​(113)​​—​​(238)
Amortization of debt issuance costs​​(325)​​—​​(325)​​—
Loss on induced conversion​​—​​—​​—​​(1,180)
Finance charges​​(7)​​(9)​​(20)​​(23)
Gain on restructuring of payables​​—​​80​​—​​80
Loss on derivatives​​—​​—​​—​​(852)
Provision (benefit) for income taxes​​—​​—​​—​​—
Segment net (loss) income​​(22,607)​​(4,768)​​(28,147)​​14,459
Reconciliation of profit or loss:​​​​​​​​​​​​
Adjustments or reconciling items​​—​​—​​—​​—
Consolidated net (loss) income​$(22,607)​$(4,768)​$(28,147)​$14,459

(1) The significant expense categories and amounts align with the segment-level information that is regularly provided to the CODM.

(2) General and administrative expense for the three months ended November 30, 2025, and 2024 is net of approximately $0.1 million and $0.3 million, respectively, of stock-based compensation expense, and for the six months ended November 30, 2025 is net of approximately $0.2 million and $0.5 million, respectively, of stock-based compensation expense.

(3) Research and development expense for the three months ended November 30, 2025 and 2024 is net of $0.1 million and $0.2 million, respectively, of stock-based compensation expense, and for the six months ended November 30, 2025 and 2024 is net of approximately $0.2 million of stock-based compensation expense. For the six months ended November 30, 2024, research and development expense is net of $25.0 million return of clinical expenses due to the settlement with Amarex. See Note 9, Commitments and Contingencies – Legal Proceedings – Settlement of Amarex Dispute in the 2025 Form 10-K for additional discussion.

Note 12. Subsequent Events

Note conversion

In December 2025, in satisfaction of the required monthly payment, the Company and the April 23, 2021 Noteholder entered into an exchange agreement, pursuant to which a portion of the April 23, 2021 Note was partitioned into a new note with an aggregate principal amount of approximately $0.8 million. The new note was exchanged concurrently for approximately 2.6 million shares.

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