Cryoport, Inc.

In addition to the other information set forth in this Quarterly Report, including the risk factor set forth below, you should carefully consider the risk factors described in Part I, Item 1A, Risk Factors, in the 2024 Annual Report, which could materially and adversely affect our business, financial condition and results of operations. These risk factors do not identify all of the risks that we face. Our business, financial condition and results of operations could also be affected by factors that are not presently known to us or that we currently consider to be immaterial.

Our business operations, financial performance and results of operations could be materially adversely affected by the continued U.S. federal government shutdown.

Some of our customers receive funding from the U.S. federal government. The delays and uncertainties in federal funding caused by the shutdown may cause some of our customers to delay purchasing our products and services. Additionally, some of our customers are subject to oversight by federal agencies. A government shutdown or understaffing at applicable federal agencies could result in unforeseen delays for some of our customers, which could also cause these customers to delay purchasing our products and services. A delay in purchases of our products and services resulting from the continued U.S. federal government shutdown could materially and adversely affect our results of operations, cash flows and liquidity.