Simulations Plus, Inc.

Rule 10b5-1 Trading Plans

The adoption, modification or termination of contracts, instructions, or written plans for the purchase or sale of our securities by our Section 16 officers and directors for the quarter ended February 28, 2026, each of which is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act (“Rule 10b5-1 Plan”), were as follows:

(1)On December 4, 2025, Walter Woltosz and his spouse entered into a Plan, which provides for the potential sale of up to 360,000 shares of Company common stock. The Plan expires on February 3, 2028, or upon the earlier upon completion or expiration of all transactions subject to the Plan.

(2) On January 14, 2026, John DiBella entered into a new Plan, which provides for the potential sale of up to 10,000 shares of Company common stock. The new plan expires on April 30, 2027, or upon the earlier completion of all authorized transactions under the Plan.

(3)On February 9, 2026, Jill Fiedler-Kelly entered into a Plan, which provided for the potential exercise of vested stock options and the associated sale of up to 9,400 shares of Company common stock underlying such options. The Plan expires on February 15, 2027, or upon the earlier completion or expiration of all transactions subject to the Plan.

The Rule 10b5-1 trading arrangements described above were adopted and precleared in accordance with the Company’s Insider Trading Policy and actual sale transactions made pursuant to such trading arrangements will be disclosed publicly in future Section 16 filings with the SEC.

Other than those disclosed above, none of our directors or officers adopted orterminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” in each case as defined in Item 408 of Regulation S-K.