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PLUS THERAPEUTICS, INC.

For the period ended Jun 30, 2025. Filed Aug 14, 2025.

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About this filing

A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.

Jun 30, 2025 · Filed Aug 14, 2025

CNSY$0.57-11.3%Stored close · as of Nov 9, 2026

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Item 6. Exhibits

EXHIBIT INDEX

Exhibit NumberExhibit TitleFiled with this Form 10-QIncorporated by Reference
FormFile No.Date Filed
3.1Composite Certificate of Incorporation10-K001-34375 Exhibit 3.103/11/2016
3.2Certificate of Amendment to Amended and Restated Certificate8-K001-34375 Exhibit 3.105/10/2016
3.3Certificate of Amendment to Amended and Restated Certificate8-K001-34375 Exhibit 3.105/23/2018
3.4Certificate of Amendment to Amended and Restated Certificate8-K001-34375 Exhibit 3.107/29/2019
3.5Certificate of Amendment to Amended and Restated Certificate8-K001-34375 Exhibit 3.108/06/2019
3.6Certificate of Amendment to Amended and Restated Certificate8-K001-34375 Exhibit 3.104/28/2023
3.7Certificate of Amendment to the Certificate of Incorporation, as amended8-K001-34375 Exhibit 3.105/02/2025
3.8Amended and Restated Bylaws of Plus Therapeutics, Inc.8-K001-34375Exhibit 3.109/21/2021
3.9Certificate of Designation of Preferences, Rights and Limitations of Series B Convertible Preferred Stock8-K001-34375Exhibit 3.111/28/2017
3.10Certificate of Designation of Preferences, Rights and Limitations of Series C Convertible Preferred Stock8-K001-34375Exhibit 3.107/25/2018
4.1Description of Securities10-K001-34375Exhibit 4.103/30/2020
4.2Form of Common Stock Certificate10-K001-34375Exhibit 4.3303/09/2018
4.3Form of Pre-Funded Warrant8-K001-34375Exhibit 4.105/09/2024
4.4Form of Amendment and Restatement of the May 2024 Series A Warrant10-Q011-34375Exhibit 4.708/14/2024
4.5Form of Amendment and Restatement of the May 2024 Series B Warrant10-Q011-34375Exhibit 4.808/14/2024
4.6Form of Amended and Restated Series B Common Stock Purchase Warrant8-K011-34375Exhibit 4.106/17/2025
4.7Form of Pre-Funded Warrant8-K011-34375Exhibit 4.102/18/2025
4.8Form of Warrant issued pursuant to the Securities Purchase and Exchange Agreement, dated February 13, 2025, by and8-K001-34375Exhibit 4.202/18/2025
among Plus Therapeutics, Inc. and the purchasers named therein
4.9Form of Pre-Funded Warrant8-K001-34375Exhibit 4.103/04/2025
4.10Form of Series A Common Stock Purchase Warrant8-K001-34375Exhibit 4.203/04/2025
4.11Form of Series B Common Stock Purchase Warrant8-K001-34375Exhibit 4.303/04/2025
4.12Form of A&R Series B Warrant8-K001-34375Exhibit 4.106/17/2025
10.1Securities Purchase and Exchange Agreement, dated February 13, 2025, by and among Plus Therapeutics, Inc. and the purchasers named therein8-K001-34375Exhibit 10.102/18/2025
10.2Form of Secured Convertible Note for Funding Notes issued pursuant to the Securities Purchase and Exchange Agreement, dated February 13, 2025, by and among Plus Therapeutics, Inc. and the purchasers names therein8-K001-34375Exhibit 10.202/18/2025
10.3Form of Secured Convertible Note for Exchange Notes issued pursuant to the Securities Purchase and Exchange Agreement, dated February 13, 2025, by and among Plus Therapeutics, Inc. and the purchasers names therein8-K001-34375Exhibit 10.302/18/2025
10.4Security Agreement, dated February 13, 2025, by and among Plus Therapeutics, Inc., CNSide Diagnostics, LLC and Iroqouis Master Fund Ltd., as collateral agent for the purchasers names therein8-K001-34375Exhibit 10.402/18/2025
10.5Subsidiary Guarantee, dated as of February 13, 2025, by and among CNSide Diagnostics, LLC and the purchasers named therein8-K001-34375Exhibit 10.502/18/2025
10.6Registration Rights Agreement, dated February 13, 2025, by and among Plus Therapeutics, Inc. and the purchasers named therein8-K001-34375Exhibit 10.602/18/2025
10.7Second Amendment to Securities Purchase Agreement, dated May 5, 2024, as amended on May 9, 2024, by and among Plus Therapeutics, Inc. and the purchasers named therein8-K001-34375Exhibit 10.702/18/2025
10.8Securities Purchase Agreement, dated as of March 4, 20258-K001-34375Exhibit 10.103/04/2025
10.9Registration Rights Agreement, dated as of March 4, 20258-K001-34375Exhibit 10.203/04/2025
10.10First Amendment to Securities Purchase and Exchange Agreement, dated as of March 4, 20258-K001-34375Exhibit 10.303/04/2025
10.11Form of Letter Agreement8-K001-34375Exhibit 10.106/17/2025
10.12Purchase Agreement, dated June 17, 2025, by and between Plus Therapeutics, Inc. and Lincoln Park Capital Fund, LLC8-K001-34375Exhibit 10.106/20/2025
10.13Registration Rights Agreement, dated June 17, 2025, by and between Plus Therapeutics, Inc. and Lincoln Park Capital Fund, LLC8-K001-34375Exhibit 10.206/20/2025
10.14Form of Support Letter, dated July 11, 2025, by and between Plus Therapeutics, Inc. and certain holdersS-1333-289526Exhibit 10.4108/12/2025
10.15Amended & Restated 2020 Stock Incentive Plan, amended August 7, 2025X
31.1*Certification of Principal Executive Officer Pursuant to Securities Exchange Act Rule 13a-1.04(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
31.2*Certification of Principal Financial and Accounting Officer Pursuant to Securities Exchange Act Rule 13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
32.1*Certifications Pursuant to 18 U.S.C. Section 1350/ Securities Exchange Act Rule 13a-14(b), as adopted pursuant to Section 906 of the Sarbanes - Oxley Act of 2002
101.INSInline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL documentX
101.SCHInline XBRL Schema DocumentX
101.CALInline XBRL Calculation Linkbase DocumentX
101.DEFInline XBRL Definition Linkbase DocumentX
101.LABInline XBRL Label Linkbase DocumentX
101.PREInline XBRL Presentation Linkbase DocumentX
104Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)X
  • In accordance with Item 601(b)(32)(ii) of Regulation S‑K and SEC Release No. 34‑47986, the certifications furnished in Exhibits 31.1, 31.2 and 32.1 hereto are deemed to accompany this Form 10‑Q and will not be deemed “filed” for purposes of Section 18 of the Exchange Act or deemed to be incorporated by reference into any filing under the Exchange Act or the Securities Act of 1933 except to the extent that the Company specifically incorporates them by reference.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

PLUS THERAPEUTICS, INC.
By:/s/ Marc H. Hedrick
Dated: August 14, 2025Marc H. Hedrick
President & Chief Executive Officer (Duly Authorized Officer and Principal Executive Officer)
By:/s/ Andrew Sims
Dated: August 14, 2025Andrew Sims
Chief Financial Officer (Duly Authorized Officer and Principal Financial Officer and Principal Accounting Officer)
ContentsView on SEC.gov

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