Tempest Therapeutics, Inc.

Retention Agreement

On May 13, 2025, we entered into a retention agreement with Justin Trojanowski, our principal accounting officer. Pursuant to the retention agreement, we expect to pay Mr. Trojanowski a cash advance of $100 thousand in May 2025 (the “Retention Bonus”) as consideration for his continued service through July 31, 2025 (the “Retention Period”). In the event that Mr. Trojanowski’s employment with the Company is terminated prior to the end of the Retention Period due to (i) Mr. Trojanowski’s resignation for any reason other than Good Reason, or (ii) by the Company for Cause (each as defined in the Retention Agreement), Mr. Trojanowski will be required to repay to the Company, within ten (10) days following the date of his employment termination, a pro rata amount of the Retention Bonus (the “Retention Bonus Clawback”). The Retention Bonus Clawback will not apply if Mr. Trojanowski’s employment is terminated during the Retention Period due to a termination by the Company without Cause. The Retention Agreement does not modify any existing employment, severance, or other agreement between the Company and Mr. Trojanowski.

Insider Trading Arrangements

During our last fiscal quarter, no director or officer (as defined in Rule 16a-1(f) under the Exchange Act)adopted orterminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.