PRECISION BIOSCIENCES INC

Rule 10b5-1 Trading Plans

On August 2, 2024, Michael Amoroso, our President and Chief Executive Officer, entered into a sell-to-cover instruction letter intended to satisfy the affirmative defense conditions under Rule 10b5-1(c). Mr. Amoroso’s instruction letter provides for sales of such number of shares of our common stock as are necessary to satisfy the applicable tax withholding obligations arising from the vesting of Restricted Stock Units (“RSUs”) granted to him. The total number of shares that may be sold pursuant to the sell-to-cover instruction letter is not determinable. Mr. Amoroso’s instruction letter may only be modified, terminated or amended by a signed writing provided by Mr. Amoroso during an open trading window under the Company’s insider trading policies.

On October 1, 2024, Alex Kelly, our Chief Financial Officer, entered into a sell-to-cover instruction letter intended to satisfy the affirmative defense conditions under Rule 10b5-1(c). Mr. Kelly’s instruction letter provided for sales of such number of shares of our common stock as were necessary to satisfy the applicable tax withholding obligations arising from the vesting of RSUs granted to him. The total number of shares that may have been sold pursuant to the sell-to-cover instruction letter was not determinable. Mr. Kelly’s instruction letter wasterminated on December 27, 2024, by a signed writing provided by Mr. Kelly during an open trading window under the Company’s insider trading policies.