Cyclerion Therapeutics Inc

On August 5, 2024, the Board of Directors of Cyclerion Therapeutics, Inc. (the “Company”) unanimously elected Regina Graul, Ph.D. as a member of the Board of Directors of the Company, effective as of such date and amended her Offer Letter, dated November 30, 2023, to include (i) a title change from President to President and Chief Executive Officer, (ii) an increase to her annual base compensation from $372,000 to $420,000, (iii) up to $100,000 of incentive bonus opportunities tied to entering into future material licensing arrangements approved by the Board of directors as qualifying for the bonus, and (iv) the grant of a stock option to purchase up to 55,849 shares of common stock of the Company, subject to certain vesting requirements, all as described in further detail in the Offer Letter Amendment attached to this Form 10-Q as Exhibit 10.1. The description of the Offer Letter Amendment in this Item 5 of this Report on Form 10-Q is not complete and is qualified in its entirety by reference to the complete text of the Offer Letter Amendment, a copy of which is attached as Exhibit 10.1 to this Quarterly Report on Form 10-Q and is incorporated herein by reference.

During the 2024 second quarter, no director or Section 16 officer adopted or terminated any Rule 10b5-1 plans or non-Rule 10b5-1 trading arrangements.