Nkarta Inc
For the period ended Mar 31, 2024. Filed May 9, 2024.
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Mar 31, 2024 · Filed May 9, 2024
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Notes to Unaudited Condensed Financial Statements
NOTES TO FINANCIAL STATEMENTS
(Unaudited)
- Organization and Description of Business
Description of the Business
Nkarta, Inc. ("Nkarta" or the "Company") was incorporated in the State of Delaware in July 2015. The Company is a biopharmaceutical company developing engineered natural killer ("NK") cell therapies to treat cancer and autoimmune disease. The Company is focused on leveraging the natural potent power of NK cells to identify and kill abnormal cells and recruit adaptive immune effectors to generate responses that are specific and durable. Nkarta is combining its NK-cell expansion platform technology with proprietary cell engineering technologies to generate an abundant supply of NK cells, engineer enhanced NK-cell recognition of therapeutic targets, and improve persistence for sustained activity in the body. Nkarta’s goal is to develop off-the-shelf NK-cell therapy product candidates to improve outcomes for patients. The Company’s operations are based in South San Francisco, California, and it operates inone segment.
Liquidity and Management Plans
The accompanying unaudited condensed financial statements have been prepared assuming that the Company will continue as a going concern. Since inception, the Company has devoted substantially all of its efforts to organizing and staffing, business planning, raising capital, conducting preclinical studies and initiating clinical studies, and has not realized substantial revenues from its planned principal operations. In addition, the Company has a limited operating history, has incurred operating losses since inception and expects that it will continue to incur net losses into the foreseeable future as it continues its research and development activities. As of March 31, 2024, the Company had an accumulated deficit of $465.0 million and cash, cash equivalents, restricted cash and investments of $450.0 million.
Management plans to continue to incur substantial costs in order to conduct research and development activities for which additional capital will be needed. The Company intends to raise such capital through debt or equity financings or other arrangements to fund operations. Management believes that the Company’s current cash, cash equivalents, restricted cash and investments will provide sufficient funds to enable the Company to meet its obligations for at least twelve months from the filing date of this report.
On March 17, 2023, the Company filed a Registration Statement on Form S-3, as amended by the Form S-3/A filed on April 24, 2023 (the "Shelf Registration Statement"), covering the offer and sale from time to time, pursuant to Rule 415 of the Securities Act of 1933, as amended (the "Securities Act"), of up to $350.0 million in aggregate offering price of shares of the Company’s common stock, shares of the Company’s preferred stock, debt securities, warrants, rights and/or units, including up to $120.0 million in aggregate offering price of shares of the Company’s common stock, shares of the Company’s preferred stock, debt securities, warrants, rights and/or units registered on the Company’s Registration Statement on Form S-3 declared effective by the Securities and Exchange Commission (the "SEC") on September 2, 2021 (the "Prior Registration Statement") that have not yet been sold. The Shelf Registration Statement was declared effective by the SEC on May 5, 2023.
On August 12, 2021, the Company entered into a sales agreement with Cowen and Company, LLC, a sales agent, to provide for the offering, issuance and sale of up to an aggregate of $150.0 million of the Company’s common stock through an “at-the-market” equity offering program (the "ATM Offering Program") pursuant to the Prior Registration Statement and subject to the limitations thereof. For the three months ended March 31, 2024, no sales of the Company’s common stock were made pursuant to the ATM Offering Program.
On March 27, 2024, the Company completed an underwritten public offering utilizing the Shelf Registration Statement, pursuant to which it sold an aggregate of (i)21,010,000 shares of its common stock at a price of $10.00 per share, and (ii) pre-funded warrants to purchase 3,000,031 shares of common stock at a price of $9.9999 per pre-funded warrant. The pre-funded warrants can be exercised at any time after issuance for an exercise price of $0.0001 per share, subject to certain ownership limitations. The Company raised $240.1 million in gross proceeds before underwriting discounts, commissions and other expenses of $15.0 million. See Note 9 for additional detail.
- Basis of Presentation and Significant Accounting Policies
Basis of Presentation
The accompanying unaudited condensed financial statements as of March 31, 2024 and for the three months ended March 31, 2024 and 2023 have been prepared in accordance with U.S. generally accepted accounting principle ("U.S. GAAP") for interim financial information and pursuant to Article 10 of Regulation S-X of the Securities Act, as amended. Accordingly, they do not include all of the information and notes required by U.S. GAAP for complete financial statements. These unaudited condensed financial statements include only normal and recurring adjustments that the Company believes are necessary to fairly state the Company’s financial position and the results of its operations and cash flows for the periods presented.
The results for the three months ended March 31, 2024 are not necessarily indicative of the results expected for the full year or any subsequent interim period. The condensed balance sheet as of December 31, 2023 has been derived from the audited financial statements at that date but does not include all disclosures required by U.S. GAAP for complete financial statements. Because all of the disclosures required by U.S. GAAP for complete financial statements are not included herein, these unaudited condensed financial statements and the notes accompanying them should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2023, contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2023 filed by the Company with the SEC on March 21, 2024.
Use of Estimates
The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the Company’s financial statements and accompanying notes. On an ongoing basis, management evaluates its estimates, including those related to preclinical studies and clinical trial accruals, fair value of assets and liabilities, impairment of assets, leases, share-based compensation and income taxes. Management bases its estimates on historical experience, knowledge of current events and actions it may undertake in the future that management believes to be reasonable under the circumstances. Actual results may differ from these estimates and assumptions.
Net Loss Per Share
Basic net loss per share is calculated by dividing the net loss by the weighted average number of common shares and pre-funded warrants outstanding for the period, without consideration of potential dilutive securities. Pre-funded warrants are considered outstanding for the purposes of computing basic and diluted net loss per share because shares may be issued for little or no additional consideration and are fully vested and exercisable after the original issuance date of the pre-funded warrants. Diluted net loss per share is computed by dividing the net loss by the sum of the weighted average number of common shares and pre-funded warrants plus the potential dilutive effects of potential dilutive securities outstanding during the period. Potential dilutive securities are excluded from diluted earnings or loss per share if the effect of such inclusion is antidilutive. The Company’s potentially dilutive securities, which include unvested common stock, outstanding stock options and restricted stock units under the Company’s equity incentive plans, have been excluded from the computation of diluted net loss per share as they would be antidilutive to the net loss per share. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding due to the Company’s net loss position.
Long-Lived Asset Impairment
The Company assesses the impairment of long-lived assets whenever events or changes in business circumstances indicate that the carrying amounts of the asset or group of assets may not be fully recoverable. In the case of property and equipment and right-of-use assets for the Company's leases, the Company determines whether there has been an impairment by comparing the carrying value of the group of assets to the anticipated undiscounted net future cash flows associated with the group of assets. If such cash flows are less than the carrying value, the Company writes down the group of assets to its fair value, which may be measured as anticipated net cash flows associated with the group of assets, discounted at a rate that the Company believes a market participant would utilize to reflect the risks associated with the cash flows, such as credit risk. See Note 6 for additional information regarding the prior year impairment charge the Company recorded in connection with its leased facilities.
Recent Accounting Pronouncements
In November 2023, the Financial Accounting Standard Board ("FASB") issued Accounting Standards Update ("ASU") No. 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires disclosure of incremental segment information on an interim and annual basis. This ASU is effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal periods beginning after December 15, 2024, and requires retrospective application to all prior periods presented in the financial statements. The Company is currently evaluating the impact of the guidance on the financial statements and disclosures.
In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures ("ASU 2023-09"). ASU 2023-09 is intended to enhance the transparency and decision usefulness of income tax disclosures. The amendments in ASU 2023-09 address investor requests for enhanced income tax information primarily through changes to the rate reconciliation and income taxes paid information. ASU 2023-09 will be effective for us in the annual period beginning January 1, 2025, though early adoption is permitted. The Company is currently evaluating the presentational effect that ASU 2023-09 will have on its financial statements.
In August 2020, the FASB issued ASU No. 2020-06, Debt-Debt with Conversion and Other Options (Subtopic 740-20) and Derivative and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity (“ASU 2020-06”), which simplifies accounting for convertible instruments by removing major separation models required under current GAAP. ASU 2020-06 also removes certain settlement conditions that are required for equity-linked contracts to qualify for the derivative scope exception, and it simplifies the diluted earnings per share calculation in certain areas. ASU 2020-06 is effective for the Company beginning on January 1, 2024. The adoption of ASU 2020-06 does not have a material impact on the financial position, results of operations or cash flows of the Company.
There were no other significant updates to the recently issued accounting standards other than as disclosed herewith. Although there are several other new accounting pronouncements issued or proposed by the FASB, the Company does not believe any of those accounting pronouncements have had or will have a material impact on its financial position or operating results.
- Net Loss Per Share
The following tables summarize the computation of the basic and diluted net loss per share (in thousands except share and per share data):
| Three Months EndedMarch 31, | ||
|---|---|---|
| 2024 | 2023 | |
| Numerator: | ||
| Net loss | $(29,518) | $(30,815) |
| Denominator: | ||
| Weighted average common shares outstanding | 50,517,632 | 48,921,535 |
| Less: weighted average unvested common stock issued upon early exercise of common stock options | — | (209) |
| Add: weighted average of common stock to be issued upon exercise of pre-funded warrants | 164,837 | — |
| Weighted average shares used to compute net loss per share, basic and diluted | 50,682,469 | 48,921,326 |
| Net loss per share, basic and diluted | $(0.58) | $(0.63) |
The following table summarizes the outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share because their inclusion would be antidilutive:
| As of March 31, | ||
|---|---|---|
| 2024 | 2023 | |
| Common stock options | 8,261,949 | 6,820,096 |
| Restricted stock units | 1,216,817 | 799,930 |
| Unvested common stock upon early exercise of common stock options | — | 113 |
| 9,478,766 | 7,620,139 | |
- Fair Value of Financial Instruments
The following tables summarize the fair value of the Company’s financial instruments (in thousands):
| Fair Value Measurements Using | ||||
|---|---|---|---|---|
| March 31,2024 | Quoted Pricesin ActiveMarkets forIdentical Assets(Level 1) | SignificantOtherObservableInputs(Level 2) | SignificantUnobservableInputs(Level 3) | |
| Assets: | ||||
| Cash equivalents: | ||||
| Money market funds | $249,867 | $249,867 | $— | $— |
| Short-term investments: | ||||
| Corporate debt securities | $38,843 | $— | $38,843 | $— |
| Commercial paper | 28,676 | — | 28,676 | — |
| U.S. Government securities | 119,590 | — | 119,590 | — |
| Total short-term investments | 187,109 | — | 187,109 | — |
| Long-term investments: | ||||
| Corporate debt securities | 9,814 | — | 9,814 | $— |
| Total long-term investments | 9,814 | — | 9,814 | — |
| Total | $446,790 | $249,867 | $196,923 | $— |
| Fair Value Measurements Using | ||||
|---|---|---|---|---|
| December 31,2023 | Quoted Pricesin ActiveMarkets forIdentical Assets(Level 1) | SignificantOtherObservableInputs(Level 2) | SignificantUnobservableInputs(Level 3) | |
| Assets: | ||||
| Cash equivalents: | ||||
| Money market funds | $30,751 | $30,751 | $— | $— |
| Short-term investments: | ||||
| Corporate debt securities | $40,609 | $— | $40,609 | $— |
| Commercial paper | 38,197 | — | 38,197 | — |
| Government securities | 138,343 | — | 138,343 | — |
| Total short-term investments | 217,149 | — | 217,149 | — |
| Total | $247,900 | $30,751 | $217,149 | $— |
Cash Equivalents and Investments
Financial assets measured at fair value on a recurring basis consist of the Company’s cash equivalents and investments. Cash equivalents consisted of money market funds and investments consisted of commercial paper, government securities and corporate bonds. The Company obtains pricing information from its investment manager and generally determines the fair value of investment securities using standard observable inputs, including reported trades, broker/dealer quotes, and bids and/or offers.
Investments are classified as Level 1 within the fair value hierarchy if their quoted prices are available in active markets for identical securities. Investments in money market funds of $249.9 million and $30.8 million as of March 31, 2024 and December 31, 2023, respectively, were classified as Level 1 instruments and were included in cash and cash equivalents.
Investments in corporate debt securities, commercial paper and Government securities included in short-term and long-term investments are valued using Level 2 inputs. Level 2 securities are initially valued at the transaction price and subsequently valued and reported upon utilizing inputs other than quoted prices that are observable either directly or indirectly, such as quotes from third-party pricing vendors. Fair values determined by Level 2 inputs, which utilize data points that are observable such as quoted prices, interest rates and yield curves, require the exercise of judgment and use of estimates, that if changed, could significantly affect the Company’s financial position and results of operations. The marketable securities of $196.9 million and $217.1 million as of March 31, 2024 and December 31, 2023, respectively, were classified as Level 2 instruments. As of March 31, 2024, marketable securities of $187.1 million were included in short-term investments, and marketable securities of $9.8 million were included in long-term investments.
Accrued interest receivable related to investments was $1.2 million as of March 31, 2024 and December 31, 2023, and included as part of prepaid expenses and other current assets in the condensed balance sheets.
The following tables summarize the Company’s short-term and long-term investments as of March 31, 2024 and December 31, 2023 (in thousands):
| Maturity(in years) | AmortizedCost | UnrealizedLosses | UnrealizedGains | EstimatedFair Value | |
|---|---|---|---|---|---|
| Corporate debt securities | 1 year or less | $38,863 | $(25) | $5 | $38,843 |
| Commercial paper | 1 year or less | 28,684 | (8) | — | 28,676 |
| U.S. Government securities | 1 year or less | 119,668 | (82) | 4 | 119,590 |
| Corporate debt securities | Greater than 1 year | 9,835 | (21) | — | 9,814 |
| Total | $197,050 | $(136) | $9 | $196,923 |
| Maturity(in years) | AmortizedCost | UnrealizedLosses | UnrealizedGains | EstimatedFair Value | |
|---|---|---|---|---|---|
| Corporate debt securities | 1 year or less | $40,602 | $(11) | $18 | $40,609 |
| Commercial paper | 1 year or less | 38,198 | (2) | 1 | 38,197 |
| Government securities | 1 year or less | 138,341 | (56) | 58 | 138,343 |
| Total | $217,141 | $(69) | $77 | $217,149 |
The Company has classified its investment securities as current and non-current assets on the condensed balance sheets based on each security's contractual maturity date, and all investment securities are accounted for as available-for-sale because these investment securities are considered available for use in current operations.
The Company considers whether unrealized losses have resulted from a credit loss or other factors. The unrealized losses on the Company’s available-for-sale securities as of March 31, 2024 and December 31, 2023 were caused by fluctuations in market value and interest rates as a result of the economic environment and not credit risk. The Company concluded that an allowance for credit losses was unnecessary as of March 31, 2024 and December 31, 2023. It is neither management’s intention to sell nor is it more likely than not that the Company will be required to sell these investments prior to recovery of their cost basis or recovery of fair value. Unrealized gains and losses are included in accumulated other comprehensive loss.
There wasno realized gain or loss on available-for-sale securities for the three months ended March 31, 2024. During the three months ended March 31, 2023, there were immaterial realized gains recognized on available-for-sale securities sold in the period. The Company uses the specific identification method to determine the cost basis of investments sold.
- Balance Sheet Components
Property and Equipment, Net
Property and equipment, net is comprised of the following (in thousands):
| March 31,2024 | December 31,2023 | |
|---|---|---|
| Leasehold improvements | $66,618 | $66,618 |
| Furniture and fixtures | 746 | 745 |
| Research equipment | 15,430 | 14,298 |
| Computers and software | 404 | 404 |
| Construction in progress | 9,273 | 8,954 |
| Total property and equipment, gross | 92,471 | 91,019 |
| Less accumulated depreciation and amortization | (13,949) | (11,693) |
| Total property and equipment, net | $78,522 | $79,326 |
Depreciation and amortization expense was $2.3 million and $0.8 million for the three months ended March 31, 2024, and 2023, respectively.
Accrued and Other Current Liabilities
Accrued other current liabilities are comprised of the following (in thousands):
| March 31,2024 | December 31,2023 | |
|---|---|---|
| Accrued compensation | $3,774 | $6,722 |
| Accrued research and development costs | 7,452 | 5,845 |
| Accrued property and equipment | 91 | 174 |
| Accrued stock issuance costs | 615 | — |
| Other accrued and current liabilities | 1,002 | 855 |
| Total accrued and other liabilities | $12,934 | $13,596 |
- Leases
The Company has operating leases for its current corporate offices, laboratories, manufacturing facilities, and dedicated space in a vivarium in South San Fran cisco, California. Rent expense was $2.7 million for the three months ended March 31, 2024, and 2023. The total cash paid for the three months ended March 31, 2024 for operating leases included in the operating cash flows was $3.3 million, inclusive of $3.1 million of rent payments and $0.2 million of tenant improvement allowance repayment, as compared to net cash received of $5.8 million for the three months ended March 31, 2023, comprised of $7.8 million cash received for the tenant improvement allowance reimbursement less $2.0 million of rent payment. The weighted average remaining lease term was 9.6 years for the corporate office, laboratory space leases, and additional facility as of March 31, 2024. The weighted average discount rate was 9.8% as of March 31, 2024.
Initial Lease Agreement
In May 2018, the Company entered into a lease agreement for corporate office and laboratory space located in South San Francisco, California with an expiration date in May 2025 (the "Initial Lease Agreement"). In April 2019, the Company executed the first amendment to the Initial Lease Agreement for additional corporate space, laboratory space and manufacturing capabilities. In May 2020, the Company executed the second amendment to the Initial Lease Agreement for additional corporate space and laboratory space in the same building. The lease for this additional space commenced in January 2021. In January 2021, the Company signed a third amendment to the Initial Lease Agreement for additional space in the same building. The lease amendment for this additional space commenced in April 2021 and expired in March 2024. In October 2021, the Company signed a fourth amendment to the Initial Lease Agreement for additional space in the same building, that commenced in April 2022. All space leased under the Initial Lease Agreement, together with the first amendment, second amendment, and fourth amendment to the Initial Lease Agreement, has a lease term through July 31, 2030, with anoption to extend the lease for an additional seven-year term. This lease extension option was not considered in the right-of-use assets or the lease liability as the Company did not consider it reasonably certain the option would be exercised.
Additional Lease Agreement
In July 2021, the Company entered into an additional lease agreement for corporate office, manufacturing and laboratory space located in South San Francisco, California with an expiration date approximately twelve years after the lease commencement date (as amended from time to time, the "Additional Lease Agreement"). The lease for this additional space and the Company's obligation to pay rent commenced in January 2022. In addition to base rent, the Company is responsible for payment of direct expenses, which include operating, insurance and tax expenses. The Additional Lease Agreement provided for certain tenant improvement allowances that were fully utilized and reimbursed to the Company, and an additional tenant improvement allowance to be utilized at the option of the Company. In June 2023, the Company entered into an amendment to utilize the additional tenant improvement allowance of $4.4 million and under this amendment the Company is required to repay the tenant improvement costs in equal monthly payments at an annual rate of 8.5% over the remainder of the lease term starting in July 2023.
Maturities of operating lease liabilities under existing operating leases as of March 31, 2024 were as follows (in thousands):
| Year ending December 31, | Amount |
|---|---|
| 2024 (remaining nine months) | $9,545 |
| 2025 | 13,027 |
| 2026 | 13,462 |
| 2027 | 13,912 |
| 2028 | 14,378 |
| 2029 and thereafter | 72,876 |
| Total undiscounted future minimum lease payments | 137,200 |
| Less imputed interest | (50,026) |
| Total operating lease liabilities | $87,174 |
| Operating lease liabilities: | |
| Current | 6,078 |
| Non-current | 81,096 |
| Total lease liability | $87,174 |
Lease Impairment
The Company tests long-lived assets for recoverability whenever events or changes in circumstances suggest that the carrying value of an asset or group of assets may not be recoverable. Beginning in the second quarter of 2023, the Company started to market for sublease portions of the Company's leased corporate office space in South San Francisco. As a result of these plans, the Company reviewed these spaces for impairment. As part of the impairment evaluation of the spaces being marketed for sublease, the Company compared the estimated undiscounted income for the marketed sublease spaces to the net book value of the related long-term assets, which include right-of-use assets and certain property and equipment, primarily for leasehold improvements (collectively, "Sublease Asset Group"). The Company estimated potential sublease income using market participant assumptions, which the Company evaluated based on current real estate trends and market conditions. For the Sublease Asset Group, the Company determined that the respective right-of-use assets had net carrying values that exceeded their estimated undiscounted future cash flows. Accordingly, the Company then estimated the fair value of the Sublease Asset Group based on its discounted cash flows. The carrying value of the Sublease Asset Group exceeded its fair values and, as a result, the Company recorded a right-of-use asset impairment of $4.1 million for the six months ended June 30, 2023. The impairment is recorded within general and administrative expenses in the condensed statements of operations and comprehensive loss. There wasno additional impairment recorded for the three months ended March 31, 2024.
- Commitments & Contingencies
Guarantee Agreement
The Company has agreements whereby it indemnifies its officers and directors for certain events or occurrences while the officer or director is, or was, serving at the Company’s request in such capacity. The term of the indemnification period is for the officer’s or director’s lifetime. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited; however, the Company has a director and officer insurance policy that limits its exposure and enables the Company to recover a portion of any future amounts under certain circumstances and subject to deductibles and exclusions. The Company hadno liabilities recorded for these agreements as of March 31, 2024, and December 31, 2023.
Letters of Credit
The Company has $2.7 million in letter of credit agreements with a financial institution that are used as collateral for the Company’s corporate headquarters’ operating leases. The letters of credit automatically renew annually without amendment unless cancelled by the financial institutions within 30 to 60 days of the annual expiration date. The letters of credit are presented as restricted cash in the condensed balance sheet.
Contingencies
The Company, from time to time, may be involved in litigation arising in the ordinary course of business. The Company assesses its potential liability in such situations by analyzing potential outcomes, assuming various litigation, regulatory and settlement strategies. If the Company determines a loss is probable and its amount can be reasonably estimated, the Company accrues an amount equal to the estimated loss. No losses andno provision for a loss contingency have been recorded to date.
Purchase Commitments
The Company enters into contracts in the normal course of business for clinical trials, preclinical studies, manufacturing and other services and products for operating purposes. These contracts generally provide for termination following a certain period after notice and therefore the Company believes that non-cancelable obligations under these agreements are not material.
- CRISPR Collaboration Agreement
On May 5, 2021, the Company entered into a research collaboration agreement (as amended, the "CRISPR Agreement") with CRISPR Therapeutics AG ("CRISPR") to co-develop and co-commercialize an allogeneic, off-the-shelf chimeric antigen receptor-natural killer ("CAR NK") product candidate targeting the CD70 tumor antigen ("NKX070") and an allogeneic, off-the-shelf product candidate that comprises both engineered NK cells and engineered T cells ("NK+T"). In May 2022, the CRISPR Agreement was amended to revise the transfer of materials and nomination provisions. On March 8, 2023, the CRISPR Agreement was further amended to permit Nkarta's advancement of CRISPR-licensed product candidates targeting a specified tumor antigen (the "Specified TA")and incorporate associated development and regulatory approval milestones and sales based royalties. In addition, the Company has received licenses from CRISPR forfour CRISPR-Cas9 gene editing targets and will receive a license from CRISPR for up toone more CRISPR-Cas9 gene editing target that can be engineered into an unlimited number of its own NK-cell products. CRISPR also has an option to co-develop and co-commercialize a future CAR NK program.
Under the terms of the CRISPR Agreement, the Company and CRISPR share equally in all research and development costs and potential profits worldwide related to the NKX070 product candidate, NK+T product candidate, and the potential future CAR NK program. For the NK+T program, CRISPR is responsible for gene-editing activities and T-cell related activities, and Nkarta is responsible for NK-cell related activities. The impact of the cost sharing associated with the research and development activities is included in research and development expense on the condensed statements of operations and comprehensive loss. Expenses related to services performed by the Company are classified as research and development expense. Payments received from CRISPR for partial reimbursement of expenses are recorded as a reduction of research and development expense. Reduction of research and development expense resulting from partial reimbursement from CRISPR was $0.1 million and $0.9 million for the three months ended March 31, 2024, and 2023, respectively. As of March 31, 2024, the Company had a $0.1 million receivable under the research cost sharing provision, which is included as part of prepaid expenses and other current assets in the condensed balance sheet.
For each non-collaboration product candidate incorporating a genome editing target licensed from CRISPR (a "CRISPR-Licensed Product Candidate"), other than those targeting the Specified TA, the Company would retain worldwide rights and may be required to make potential future payments based on the achievement of development and regulatory approval milestones totaling less than mid-twenty million dollars, as well as tiered royalties up to the mid-single digits on net product sales of such product candidate. For each CRISPR-Licensed Product Candidate targeting the Specified TA, the Company would retain worldwide rights and may be required to make potential future payments based on the achievement of development and regulatory approval milestones totaling less than high-forty million dollars, as well as tiered royalties up to the mid-single digits on net product sales of such product candidate. As of March 31, 2024, the Company hasnot paid any amountsnor are any amounts owed by the Company under the CRISPR Agreement, and no milestones have been achieved.
- Stockholders' Equity
Equity Incentive Plan
The Company’s 2020 Performance Incentive Plan (the "2020 Plan"), which was adopted by the Company’s board of directors in June 2020 and approved by the Company’s stockholders in July 2020, became effective upon the consummation of the Company’s initial public offering in July 2020 ("IPO"). Upon the effectiveness of the 2020 Plan, no further grants may be made under the Company’s 2015 Equity Incentive Plan (the "2015 Plan"). The 2020 Plan allows for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, stock bonuses, restricted stock, stock units and other forms of awards including cash awards to its officers, directors, employees, consultants and advisors.
As of March 31, 2024, a total of 10,847,981 shares of the Company’s common stock were authorized for issuance with respect to awards granted under the 2020 Plan (this number of shares gives effect to the annual increases in the 2020 Plan share limit, as described in the next sentence, through that date). The share limit will automatically increase on the first trading day in January of each year by an amount equal to the lesser of (1)5%of the total number of outstanding shares of the Company’s common stock on the last trading day in December in the prior year, or (2) such lesser number as determined by the Company’s board of directors. Any shares subject to awards granted under the 2020 Plan or the 2015 Plan that are not paid, delivered or exercised before they expire or are canceled or terminated, or otherwise fail to vest, as well as shares used to pay the purchase or exercise price of such awards or relatedtax withholding obligations, will become available for new award grants under the 2020 Plan. A total of 2,674,638 shares were available for issuance under the 2020 Plan as of March 31, 2024.
The following table summarizes the option activity under the 2020 Plan and 2015 Plan during the three months ended March 31, 2024:
| Number of shares | Weighted averageexerciseprice | Weighted averageremainingcontractualterm(in years) | Aggregate Intrinsic Value | |
|---|---|---|---|---|
| Outstanding at December 31, 2023 | 6,716,526 | $12.99 | 7.5 | 8,279 |
| Granted | 1,955,300 | 6.11 | ||
| Exercised | (128,671) | 4.49 | ||
| Forfeited | (281,206) | 22.22 | ||
| Outstanding at March 31, 2024 | 8,261,949 | $11.18 | 8.1 | 30,907 |
| Exercisable at March 31, 2024 | 3,591,101 | $15.68 | 6.8 | 9,692 |
| Vested and expected to vest at March 31, 2024 | 8,261,949 | $11.18 | 8.1 | 30,907 |
The weighted average grant date fair value of stock option grants was $4.98 and $4.22 per share for the three months ended March 31, 2024 and 2023, respectively. The intrinsic value of options exercised was $0.7 million and immaterial for the three months ended March 31, 2024 and 2023, respectively.
The following table summarizes the restricted stock unit activity under the 2020 Plan during the three months ended March 31, 2024:
| Number of shares | Weighted averagegrant date fair value per share | Weighted averageremainingcontractualterm(in years) | |
|---|---|---|---|
| Outstanding at December 31, 2023 | 594,768 | $8.16 | 1.4 |
| Granted | 775,153 | 6.01 | |
| Vested | (133,595) | 7.45 | |
| Forfeited | (19,509) | 7.22 | |
| Outstanding at March 31, 2024 | 1,216,817 | $6.88 | 2.0 |
The weighted average grant date fair value of restricted stock units was $6.01 and $5.57 per share for the three months ended March 31, 2024 and 2023, respectively. There were no restricted stock units that vested for the three months ended March 31, 2024 and 2023.
Employee Stock Purchase Plan
The Company’s 2020 Employee Stock Purchase Plan (the "ESPP"), which was adopted by the Company’s board of directors in June 2020 and approved by the Company’s stockholders in July 2020, became effective upon the consummation of the IPO. The ESPP allows eligible employees to purchase shares of the Company’s common stock at a discount through payroll deductions of up to 15% of their eligible compensation, subject to any plan limitations. The ESPP provides forsix-month offering periods, and at the end of each offering period, employees are able to purchase shares at 85% of the lower of the fair market value of the Company’s common stock on the first trading day of the offering period or on the last trading day of the offering period. The six-month offering periods extend from June to November and December to May. As of March 31, 2024,1,706,798 shares of the Company’s common stock remained available for issuance under the ESPP (after giving effect to share purchases under the ESPP, and annual increases in the ESPP share limit as described in the next sentence through that date). The number of shares of the Company’s common stock available for issuance under the ESPP automatically increases on the first trading day in January of each year by an amount equal to the lesser of (i)1% of the total number of outstanding shares of the Company’s common stock issued and outstanding on December 31 of the immediately preceding calendar year, (ii)1,000,000 shares, or (iii) such lesser number as determined by the Company’s board of directors. As of March 31, 2024, employee contributions to the ESPP were$0.3 million and included as part of accrued and other current liabilities in the condensed balance sheets.
Share-Based Compensation Expense
Share-based compensation expense for the three months ended March 31, 2024 and 2023 was as follows (in thousands):
| Three Months EndedMarch 31, | ||
|---|---|---|
| 2024 | 2023 | |
| Research and development | $2,200 | $2,082 |
| General and administrative | 2,168 | 2,664 |
| Total share-based compensation | $4,368 | $4,746 |
The total unrecognized compensation cost related to unvested stock options was $25.1 million, which is expected to be recognized over a weighted average remaining service period of 3.0 years as of March 31, 2024.
The total unrecognized compensation cost related to unvested restricted stock units was $7.6 million, which is expected to be recognized over a weighted average remaining service period of 3.3 years as of March 31, 2024.
Sale of Common Stock and Pre-funded Warrants
On March 27, 2024, the Company completed an underwritten public offering utilizing the Shelf Registration Statement, pursuant to which it sold an aggregate of (i)21,010,000 shares of its common stock at a price of $10.00 per share, and (ii) pre-funded warrants to purchase 3,000,031 shares of its common stock at a price of $9.9999 per pre-funded warrant. The pre-funded warrants can be exercised at any time after issuance for an exercise price of $0.0001 per share, subject to certain ownership limitations. As of March 31, 2024, none of the pre-funded warrants have been exercised. The Company raised $240.1 million in gross proceeds before underwriting discounts and commissions of $14.4 million and estimated other offering expenses of $0.6 million.
In accordance with ASC 480-10, Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity ("ASC 480"), and ASC 815-40 ("ASC 815"), Accounting for Derivative Financial Instruments Indexed to, and Potentially Settled in, a Company’s Own Stock, the Company determined that the pre-funded warrants should be equity classified because they are freestanding financial instruments, are immediately exercisable, do not embody an obligation for the Company to repurchase its shares, permit the holders to receive a fixed number of shares of common stock upon exercise, are indexed to the Company’s common stock and meet the equity classification criteria.
- Income Taxes
There wasno provision for income taxes recorded during the three months ended March 31, 2024 and 2023. The Company’s deferred tax assets continue to be fully offset by a valuation allowance.
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