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EyePoint Pharmaceuticals Inc

For the period ended Jun 20, 2024. Filed Apr 26, 2024.

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Jun 20, 2024 · Filed Apr 26, 2024

EYPT$0.36+1.2%Stored close · as of Nov 6, 2026
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DEF 14A 1 eypt_def_14a_04-26-2024.htm DEF 14A

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

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480 Pleasant Street, Suite C400Watertown, MA 02472 United States
April 26, 2024To Our Stockholders,2023 was an exceptional year for EyePoint as we executed on our mission to bring innovative, life-changing therapeutics to patients living with serious retinal diseases. We completed our transformation into a clinical-stage biopharmaceutical company with the out-license of the YUTIQ® franchise, and now we are focused on advancing and expanding our pipeline of innovative sustained-delivery treatments to provide a brighter future for those at risk of losing their sight.We are focused on advancing and expanding our pipeline of innovative sustained-delivery treatments to provide a brighter future for those at risk of losing their sight.
EyePoint’s bioerodible Durasert E™ drug delivery technology provides a best-in-class sustained release intravitreal insert for treating serious retinal diseases. This technology enables a constant, sustained drug release known as zero order kinetics. We have built a potential multi-billion-dollar pipeline around this innovative drug delivery technology.In 2023, we made great progress with our lead pipeline program, EYP-1901 (DURAVYU™), an investigational sustained release product that consists of vorolanib, a selective and patent-protected tyrosine kinase inhibitor, formulated in Durasert E™. During the year, we continued our record of strong execution and completed enrollment in two Phase 2 clinical trials in wet age-related macular degeneration (wAMD) and non-proliferative diabetic retinopathy (NPDR). In December 2023, we reported positive topline efficacy and safety data from our Phase 2 DAVIO 2 clinical trial in wAMD, achieving all primary and secondary endpointsWe believe these strong results underscore the potential of DURAVYU (vorolanib intravitreal insert) to be a paradigm-altering treatment for patients suffering from VEGF-mediated retinal diseases. Looking ahead, we expect to report topline data for the Phase 2 PAVIA clinical trial in NPDR in the second quarter of this year and to initiate the first pivotal Phase 3 wAMD trial, the LUGANO trial, in the second half of this year, with the second pivotal wAMD trial called the LUCIA trial to follow.In January 2024, we initiated our third Phase 2 clinical trial for DURAVYU, the VERONA trial for diabetic macular edema (DME), and we look forward to reporting topline results in the first quarter of 2025. DURAVYU brings a new mechanistic approach to the treatment of VEGF-mediated retinal diseases by combining zero order kinetic release and pan-VEGF receptor inhibition, inhibiting the effects of all VEGF isoforms, resulting in enhanced efficacy and extended durability. We remain highly encouraged by the growing body of positive clinical data for DURAVYU and its potential as a differentiated therapeutic option with sustained delivery over 6-9 months, and we are optimistic that DURAVYU has the potential to change the current treatment paradigm for VEGF-mediated retinal diseases.Turning to our early pipeline, in 2023 we announced a new preclinical program, EYP-2301, which delivers a promising TIE-2 agonist, razuprotafib, formulated in Durasert E™. We believe that delivering EYP-2301 intravitreally has the potential to offer new sight-saving treatment for patients with severe retinal disease, either alone or in combination with anti-VEGFs. We continue to evaluate additional molecules for sustained delivery in Durasert E™ including complement inhibition and rare diseases and hope to update you on those programs later this year. In addition, we significantly strengthened our balance sheet with the May 2023 out-license of YUTIQ® for $82.5 million plus future royalties and the December 2023 completion of a successful $230 million follow-on equity financing. We ended the year well-capitalized with cash and investments of $331 million with no debt.
When it comes to matters of sight, innovation is our vision.
To support our pipeline progress and meet the long-term needs of our patients, employees and shareholders, we completed a number of significant milestones in 2023 and in recent months. This includes the completion of the transition of Jay S. Duker, M.D. to President and CEO from his previous role as Chief Operating Officer and the transition of Nancy S. Lurker from CEO to Executive Vice Chair of the Board of Directors. We also appointed Stuart Duty, a seasoned veteran in biotech finance and investment banking, to EyePoint’s Board of Directors and Ramiro Ribeiro, M.D., Ph.D. as Chief Medical Officer. Dr. Ribeiro joins EyePoint from Apellis Pharmaceuticals, where he served as Vice President, Head of Clinical Development. Additionally, we promoted our Chief Financial Officer George Elston to Executive Vice President, underscoring his invaluable contributions to EyePoint’s organizational growth, financial success and strategic long-term vision. We would also like to thank Victor Liu for his years of service to EyePoint’s Board of Directors and important support of our Company during his tenure.We are grateful for the dedicated and talented team at EyePoint who continue to drive our progress and are responsible for our company’s clinical, operational, and financial success to date. In addition, we’d like to thank the patients and clinical investigators for their participation in our ongoing trials; without whom, our progress advancing DURAVYU would not be possible. With our compelling clinical pipeline representing potential multi-billion-dollar product opportunities, our best-in-class sustained ocular delivery Durasert E™ technology, along with a strong balance sheet, we're well-positioned to grow as a leader in ocular drug delivery with the potential to benefit the millions of patients at risk of serious vision loss.On behalf of the entire EyePoint team and Board of Directors, we thank you, our committed stockholders, for your continued support as we work towards providing better solutions for patients with serious retinal diseases – because when it comes to matters of sight, innovation is our vision. Sincerely, Jay S. Duker, M.D.President & Chief Executive Officer Goran Ando, M.D.Chairman of the Board DURAVYU™ has been conditionally accepted by the FDA as the proprietary name for EYP-1901. DURAVYU is an investigational product; it has not been approved by the FDA. FDA approval and the timeline for potential approval is uncertain.

SAFE HARBOR STATEMENTS UNDER THE PRIVATE SECURITIES LITIGATION ACT OF 1995: To the extent any statements made in this proxy deal with information that is not historical, these are forward-looking statements under the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements identified by words such as “will,” “potential,” “could,” “can,” “believe,” “intends,” “continue,” “plans,” “expects,” “anticipates,” “estimates,” “may,” other words of similar meaning or the use of future dates. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Uncertainties and risks may cause EyePoint’s actual results to be materially different than those expressed in or implied by EyePoint’s forward-looking statements. For EyePoint, this includes uncertainties regarding the timing and clinical development of our product candidates, including EYP-1901 and EYP-2301; the potential for EYP-1901 as a novel sustained delivery treatment for serious eye diseases, including wet age-related macular degeneration and non-proliferative diabetic retinopathy and diabetic macular edema ; the effectiveness and timeliness of clinical trials, and the usefulness of the data; the timeliness of regulatory approvals including potential U.S. Food and Drug Administration (FDA) regulatory approval of EYP-1901 and EYP-2301; the success of current and future license agreements; our dependence on contract research organizations, and other outside vendors and service providers; the success of Durasert E™ as a drug delivery platform in FDA approved products; product liability; industry consolidation; compliance with environmental laws; volatility of stock price; possible dilution; absence of dividends; the impact of general business and economic conditions; instability in macroeconomic factors including changes in inflation, interest rates and the labor market; protection of our intellectual property and avoiding intellectual property infringement; retention of key personnel; manufacturing risks; and other factors described in our filings with the Securities and Exchange Commission. We cannot guarantee that the results and other expectations expressed, anticipated or implied in any forward-looking statement will be realized. A variety of factors, including these risks, could cause our actual results and other expectations to differ materially from the anticipated results or other expectations expressed, anticipated or implied in our forward-looking statements. Should known or unknown risks materialize, or should underlying assumptions prove inaccurate, actual results could differ materially from past results and those anticipated, estimated or projected in the forward-looking statements. You should bear this in mind as you consider any forward-looking statements. Our forward-looking statements speak only as of the dates on which they are made. EyePoint undertakes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise.

NOTICE OF 2024 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD JUNE 20, 2024

Dear Stockholders:

NOTICE IS HEREBY GIVEN that the 2024 Annual Meeting of Stockholders (Annual Meeting) of EyePoint Pharmaceuticals, Inc. (the Company) will be held on June 20, 2024 at 9:00 a.m., Eastern Time. This year’s Annual Meeting will be a virtual meeting via live webcast on the Internet. You will not be able to attend the Annual Meeting in person. Instead, you will be able to attend the Annual Meeting by visiting www.meetnow.global/MWRWKS9, for the following purposes:

To elect nine directors to the Company’s Board of Directors, each to serve until the Company’s 2025 Annual Meeting of Stockholders or until such person’s successor is duly elected and qualified.

To approve an amendment to the EyePoint Pharmaceuticals, Inc. 2023 Long-Term Incentive Plan to (i) increase the number of shares of common stock authorized for issuance thereunder by 4,000,000 shares and (ii) increase the individual non-employee director compensation limit contained therein to $850,000 for ongoing directors in any calendar year and $1,100,000 for new directors in any calendar year.

To approve an amendment to the EyePoint Pharmaceuticals, Inc. 2019 Employee Stock Purchase Plan to increase the number of shares of common stock authorized for issuance thereunder by 250,000 shares.

To approve, on an advisory basis, the compensation paid to the Company’s named executive officers as disclosed in the accompanying proxy statement.

To ratify the appointment of Deloitte & Touche LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2024.

To transact such other business as may properly come before the meeting or any adjournment or postponement of the Annual Meeting.

The Company’s Board of Directors recommends that stockholders vote FOR ALL on Proposal No. 1 and FOR Proposal Nos. 2, 3, 4 & 5. During the ten days before the Annual Meeting, you may inspect a list of stockholders eligible to vote. If you would like to inspect the list, please call Jason D. Herpel, Vice President and Associate General Counsel, at (215) 817-4705 to arrange the inspection.

Stockholders of record at the close of business on April 23, 2024, the record date of the Annual Meeting, are entitled to notice of, and to vote at, the Annual Meeting and any adjournment or postponement of the meeting.

Important notice regarding the availability of proxy materials for the Annual Meeting to be held on June 20, 2024. Our 2024 Proxy Statement and Annual Report on Form 10-K for the year ended December 31, 2023 are available atwww.edocumentview.com/EYPT for street holders andwww.envisionreports.com/EYPT for registered holders.

The accompanying proxy statement includes further details with respect to the proposals to be considered at the Annual Meeting. This notice of Annual Meeting and the accompanying proxy statement contain important information and should be read in their entirety. If you are in doubt as to how you should vote at the Annual Meeting, you should seek advice from your legal counsel, accountant, or other professional adviser prior to voting.

By Order of the Board of Directors

Ron Honig

Chief Legal Officer and Company Secretary

April 26, 2024

Watertown, Massachusetts

Table of Contents

QUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS AND VOTING1
DIRECTORS AND EXECUTIVE OFFICERS8
CORPORATE GOVERNANCE AND BOARD MATTERS13
STOCK OWNERSHIP22
EXECUTIVE OFFICER AND DIRECTOR COMPENSATION24
PAY VERSUS PERFORMANCE DISCLOSURE35
PROPOSAL 1: ELECTION OF NINE DIRECTORS39
PROPOSAL 2: APPROVAL OF AMENDMENT TO 2023 LONG-TERM INCENTIVE PLAN40
PROPOSAL 3: APPROVAL OF AMENDMENT TO 2019 EMPLOYEE STOCK PURCHASE PLAN46
PROPOSAL 4: ADVISORY VOTE ON EXECUTIVE COMPENSATION49
PROPOSAL 5: RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM50
INFORMATION ABOUT STOCKHOLDER PROPOSALS AND DIRECTOR NOMINATIONS52
DELIVERY OF DOCUMENTS TO STOCKHOLDERS SHARING AN ADDRESS52
OTHER BUSINESS53
ANNEX A: AMENDMENT TO 2023 LONG TERM INCENTIVE PLAN AND THE 2023 LONG TERM INCENTIVE PLANA-1
ANNEX B: AMENDMENT TO 2019 EMPLOYEE STOCK PURCHASE PLAN AND THE 2019 EMPLOYEE STOCK PURCHASE PLANA-12

In this proxy statement, the words “EyePoint,” “the Company,” “we,” “our,” “ours,” “us”, and similar terms refer to EyePoint Pharmaceuticals, Inc. and its consolidated subsidiaries, unless the context indicates otherwise.

The Notice of 2024 Annual Meeting of Stockholders and Proxy Statement and our accompanying Annual Report on Form 10-K are being distributed and made available on or about May 6, 2024.

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