Fulcrum Therapeutics Inc

As previously disclosed, on May 9, 2022, we entered into an equity distribution agreement, or the 2022 Sales Agreement, with Piper Sandler & Co., as sales agent, with respect to an at-the-market offering program to sell shares of our common stock having an aggregate offering price of up to $50.0 million, or the 2022 Shares, from time to time through the sales agent. Effective as of the date of this Annual Report on Form 10-K, we terminated the 2022 Sales Agreement pursuant to Section 7 thereof. We are not subject to any termination penalties related to the termination of the 2022 Sales Agreement. Prior to termination, all of the 2022 Shares remained available for sale pursuant to the 2022 Sales Agreement. As a result of the termination of the 2022 Sales Agreement, we will not offer or sell any shares under the 2022 Sales Agreement.

A copy of the 2022 Sales Agreement was filed as Exhibit 1.1 to the Current Report on Form 8-K filed by us on May 10, 2022. The description of the 2022 Sales Agreement contained herein does not purport to be complete and is qualified in its entirety by reference to the copy of the 2022 Sales Agreement filed as Exhibit 1.1 to the Current Report on Form 8-K filed by us on May 10, 2022.