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IONIS PHARMACEUTICALS INC

For the period ended Jun 30, 2026. Filed Jul 29, 2026.

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About this filing

A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.

Jun 30, 2026 · Filed Jul 29, 2026

IONS$39.42+1.6%Stored close · as of Nov 6, 2026

Extracted filing text, with the paragraph anchors used by the comparison.

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Table of Contents

PART I · FINANCIAL INFORMATION
ITEM 1: · Financial Statements:
Condensed Consolidated Balance Sheets as of June 30, 2026 (unaudited) and December 31, 20253
Condensed Consolidated Statements of Operations for the three and six months ended June 30, 2026 and 2025 (unaudited)4
Condensed Consolidated Statements of Comprehensive Income (Loss) for the three and six months ended June 30, 2026 and 2025 (unaudited)5
Condensed Consolidated Statements of Stockholders’ Equity for the three and six months ended June 30, 2026 and 2025 (unaudited)6
Condensed Consolidated Statements of Cash Flows for the six months ended June 30, 2026 and 2025 (unaudited)8
Notes to Condensed Consolidated Financial Statements (unaudited)9
ITEM 2:Management’s Discussion and Analysis of Financial Condition and Results of Operations:
Overview27
Critical Accounting Estimates30
Results of Operations30
Liquidity and Capital Resources36
ITEM 3:Quantitative and Qualitative Disclosures about Market Risk38
ITEM 4:Controls and Procedures38
PART IIOTHER INFORMATION39
ITEM 1:Legal Proceedings39
ITEM 1A:Risk Factors39
ITEM 2:Unregistered Sales of Equity Securities and Use of Proceeds58
ITEM 3:Default upon Senior Securities58
ITEM 4:Mine Safety Disclosures58
ITEM 5:Other Information58
ITEM 6:Exhibits59
SIGNATURES60

TRADEMARKS

“Ionis,” the Ionis logo, and other trademarks or service marks of Ionis Pharmaceuticals, Inc. appearing in this report are the property of Ionis Pharmaceuticals, Inc. “Akcea,” the Akcea logo, and other trademarks or service marks of Akcea Therapeutics, Inc. appearing in this report are the property of Akcea Therapeutics, Inc., Ionis’ wholly owned subsidiary. This report contains additional trade names, trademarks and service marks of others, which are the property of their respective owners. Solely for convenience, trademarks and trade names referred to in this report may appear without the ® or TM symbols.

PART I — FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

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The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.