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IONIS PHARMACEUTICALS INC

For the period ended Dec 31, 2025. Filed Feb 26, 2026.

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A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.

FY2025 · Filed Feb 26, 2026

IONS$31.00-21.4%Stored close · as of Nov 9, 2026

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Contents

Item 2. Properties

As of February 19, 2026, the following are the primary facilities in which we operate:

Owned · Initial Lease · Lease
Property DescriptionLocationSquare Footageor LeasedTerm End DateExtension Options
Laboratory and office space facilityCarlsbad, CA176,300Leased2037Two, five-year options to extend
Laboratory and office space facilityCarlsbad, CA164,800Leased2040Two, five-year options to extend
Office and meeting space facilityCarlsbad, CA74,000Leased2037Two, five-year options to extend
Manufacturing facilityCarlsbad, CA26,800Owned
Manufacturing support facilityCarlsbad, CA25,800Leased2031None
Office space facilityBoston, MA14,300Leased2038None
Office space facilityCarlsbad, CA5,800Leased2027None
Warehouse facilityCarlsbad, CA4,200Leased2028None
Office space facilityDublin, Ireland3,900Leased2030None

We believe that our current and future facilities will be adequate for the foreseeable future. Refer to Part IV, Section 15, Note 7, Long-Term Obligations and Commitments, in the Notes to the Consolidated Financial Statements for details on our facilities.

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The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.