AMGEN INC
For the period ended Dec 31, 2025. Filed Feb 13, 2026.
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A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.
FY2025 · Filed Feb 13, 2026
AMGN$465.23+1.0%Stored close · as of Nov 9, 2026
Extracted filing text, with the paragraph anchors used by the comparison.
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DEFINED TERMS AND PRODUCTSii
Defined Terms and Products
Defined terms
We use several terms in this Annual Report on Form 10-K, including but not limited to those that are finance, regulation and disease-state related as well as names of other companies, which are provided below.
| Term | Description |
|---|---|
| 2017 Tax Act | Tax Cuts and Jobs Act of 2017 |
| 340B Program | Federal 340B Drug Pricing Program |
| AI | artificial intelligence |
| Amended 2009 Plan | Amended and Restated 2009 Equity Incentive Plan |
| AOCI | accumulated other comprehensive income (loss) |
| AstraZeneca | AstraZeneca plc |
| ASU | Accounting Standards Update |
| ATMOS | Amgen Technology and Medical Organizations |
| B-ALL | B-cell acute lymphoblastic leukemia |
| BeOne | BeOne Medicines Ltd. (formerly BeiGene, Ltd.) |
| BiTE® | bispecific T-cell engager |
| BLA | Biologics License Application |
| BPCIA | Biologics Price Competition and Innovation Act of 2009 |
| CCPA | California Consumer Privacy Act of 2018 |
| CDT | Cybersecurity & Digital Trust |
| CGRP | calcitonin gene-related peptide |
| ChemoCentryx | ChemoCentryx, Inc. |
| chemotherapy | anticancer medicines |
| CHMP | Committee for Medicinal Products for Human Use |
| CIO | Chief Information Officer |
| CISO | Chief Information Security Officer |
| CMS | Centers for Medicare & Medicaid Services |
| COSO | Committee of Sponsoring Organizations of the Treadway Commission |
| CRCC | Corporate Responsibility and Compliance Committee |
| DLL3 | delta-like ligand 3 |
| DOJ | U.S. Department of Justice |
| EC | European Commission |
| EMA | European Medicines Agency |
| EO | Executive Order |
| EPO | European Patent Office |
| EPS | earnings per share |
| EU | European Union |
| FASB | Financial Accounting Standards Board |
| FCPA | U.S. Foreign Corrupt Practices Act |
| FDA | U.S. Food and Drug Administration |
| FDCA | Federal Food, Drug, and Cosmetic Act |
| Fitch | Fitch Ratings, Inc. |
| GAAP | U.S. generally accepted accounting principles |
| GDPR | General Data Protection Regulation |
| GIPR | glucose-dependent insulinotropic polypeptide receptor |
| GLP-1 | glucagon like peptide 1 |
| HHS | U.S. Department of Health and Human Services |
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| Term | Description |
|---|---|
| Horizon | Horizon Therapeutics plc |
| IGF-1R | insulin-like growth factor-1 receptor |
| IgG4-RD | Immunoglobulin G4-related disease |
| IND | Investigational New Drug Application |
| IPR&D | in-process research and development |
| IRA | Inflation Reduction Act of 2022 |
| IRS | Internal Revenue Service |
| July MFN Letter | Letter dated July 31, 2025, by the Administration to a number of pharmaceutical manufacturers, including Amgen |
| KRAS | Kirsten rat sarcoma viral oncogene homologue |
| Kyowa Kirin | Kyowa Kirin Co., Ltd. |
| LDL-C | low-density lipoprotein cholesterol |
| MAA | Marketing Authorisation Application |
| MD&A | management’s discussion and analysis |
| MFN | Most-Favored-Nations |
| MFN EO | Most-Favored-Nations Prescription Drug Pricing Executive Order, dated May 12, 2025 |
| Moody’s | Moody’s Investors Service, Inc. |
| MRD | minimal residual disease |
| Neumora | Neumora Therapeutics, Inc. |
| NIH | National Institutes of Health |
| NOL | net operating loss |
| NSCLC | non-small cell lung cancer |
| OB3 | P.L. 119-21, also The One Big Beautiful Bill Act signed into law on July 4, 2025 |
| OECD | Organisation for Economic Co-operation and Development |
| PBM | pharmacy benefit manager |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 |
| PDAB | Prescription Drug Affordability Board |
| R&D | research and development |
| RANKL | receptor activator of nuclear factor kappa-B ligand |
| RAR | Revenue Agent Report |
| RAS | Rat sarcoma viral oncogene |
| REMS | Risk Evaluation and Mitigation Strategy |
| ROU | right-of-use |
| ROW | rest of world |
| RSUs | restricted stock units |
| S&P | Standard & Poor’s Financial Services LLC |
| SEC | U.S. Securities and Exchange Commission |
| SG&A | selling, general and administrative |
| SOFR | Secured Overnight Financing Rate |
| TED | thyroid eye disease |
| Teneobio | Teneobio, Inc. |
| U.S. Treasury | U.S. Department of the Treasury |
| USPTO | U.S. Patent and Trademark Office |
| UTB | unrecognized tax benefit |
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Products
The brand names of our products, our delivery devices and certain of our product candidates and their associated generic names are provided below.
| Term | Description |
|---|---|
| ACTIMMUNE | ACTIMMUNE® (interferon gamma-1b) |
| Aimovig | Aimovig® (erenumab-aooe) |
| AMJEVITA/AMGEVITA | AMJEVITA® (adalimumab-atto)/AMGEVITA™ (adalimumab) |
| Aranesp | Aranesp® (darbepoetin alfa) |
| AutoTouch | AutoTouch® |
| AVSOLA | AVSOLA® (infliximab-axxq) |
| BKEMV/BEKEMV | BKEMV® (eculizumab-aeeb)/BEKEMV™ (eculizumab) |
| BLINCYTO | BLINCYTO® (blinatumomab) |
| BUPHENYL | BUPHENYL® (sodium phenylbutyrate) |
| ConfiPen | ConfiPen™ |
| Corlanor | Corlanor® (ivabradine) |
| ENBREL | Enbrel® (etanercept) |
| ENBREL Mini | ENBREL Mini® |
| EPOGEN | EPOGEN® (epoetin alfa) |
| EVENITY | EVENITY® (romosozumab-aqqg) |
| IMDELLTRA/IMDYLLTRA | IMDELLTRA® (tarlatamab-dlle)/IMDYLLTRA™ (tarlatamab) |
| IMLYGIC | IMLYGIC® (talimogene laherparepvec) |
| KANJINTI | KANJINTI® (trastuzumab-anns) |
| KRYSTEXXA | KRYSTEXXA® (pegloticase) |
| KYPROLIS | KYPROLIS® (carfilzomib) |
| LUMAKRAS/LUMYKRAS | LUMAKRAS®/LUMYKRAS™ (sotorasib) |
| MariTide | Maridebart cafraglutide (MariTide™) |
| MVASI | MVASI® (bevacizumab-awwb) |
| Neulasta | Neulasta® (pegfilgrastim) |
| NEUPOGEN | NEUPOGEN® (filgrastim) |
| Nplate | Nplate® (romiplostim) |
| Onpro | Onpro® |
| Otezla | Otezla® (apremilast) |
| Parsabiv | Parsabiv® (etelcalcetide) |
| PAVBLU | PAVBLU® (aflibercept-ayyh) |
| PENNSAID | PENNSAID® (diclofenac sodium topical solution) 2% |
| PROCYSBI | PROCYSBI® (cysteamine bitartrate) |
| Prolia | Prolia® (denosumab) |
| QUINSAIR | QUINSAIR® (levofloxacin) |
| RAVICTI | RAVICTI® (glycerol phenylbutyrate) |
| RAYOS | RAYOS® (prednisone) |
| Repatha | Repatha® (evolocumab) |
| RIABNI | RIABNI® (rituximab-arrx) |
| Sensipar/Mimpara | Sensipar®/Mimpara™ (cinacalcet) |
| SureClick | SureClick® |
| TAVNEOS | TAVNEOS® (avacopan) |
| TEPEZZA | TEPEZZA® (teprotumumab-trbw) |
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| Term | Description |
|---|---|
| TEZSPIRE | TEZSPIRE® (tezepelumab-ekko) |
| UPLIZNA | UPLIZNA® (inebilizumab-cdon) |
| Vectibix | Vectibix® (panitumumab) |
| WEZLANA/WEZENLA | WEZLANA® (ustekinumab-auub)/WEZENLA™ (ustekinumab) |
| XGEVA | XGEVA® (denosumab) |
Products referenced in this report that are not included in the above list are the properties of their respective owners.
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