FIFTH THIRD BANCORP

Fifth Third Bancorp is a diversified financial services company headquartered in Cincinnati, Ohio. At September 30, 2026, the Bancorp had $301 billion in assets and operated 1,429 full-service banking centers and 2,549 Fifth Third ATMs in fifteen states throughout its retail footprint. The Bancorp reports on three business segments: Commercial Banking, Consumer and Small Business Banking and Wealth and Asset Management.

This overview of MD&A highlights selected information in the financial results of the Bancorp and may not contain all of the information that is important to you. For a more complete understanding of trends, events, commitments, uncertainties, liquidity, capital resources and critical accounting policies and estimates, you should carefully read this entire document as well as the Bancorp’s Annual Report on Form 10-K for the year ended December 31, 2025. Each of these items could have an impact on the Bancorp’s financial condition, results of operations and cash flows. In addition, refer to the Glossary of Abbreviations and Acronyms in this report for a list of terms included as a tool for the reader of this Quarterly Report on Form 10-Q. The abbreviations and acronyms identified therein are used throughout this MD&A, as well as the Condensed Consolidated Financial Statements and Notes to Condensed Consolidated Financial Statements.

Net interest income, net interest margin, net interest rate spread and the efficiency ratio are presented in MD&A on an FTE basis. The FTE basis adjusts for the tax-favored status of income from certain loans and leases and securities held by the Bancorp that are not taxable for federal income tax purposes. The Bancorp believes this presentation to be the preferred industry measurement of net interest income as it provides a relevant comparison between taxable and non-taxable amounts. The FTE basis for presenting net interest income is a non-GAAP measure. For further information, refer to the Non-GAAP Financial Measures section of MD&A.

The Bancorp’s revenues are dependent on both net interest income and noninterest income. For the three months ended September 30, 2026, net interest income on an FTE basis and noninterest income provided 69% and 31% of total revenue, respectively. For the nine months ended September 30, 2026, net interest income on an FTE basis and noninterest income provided 68% and 32% of total revenue, respectively. The Bancorp derives the majority of its revenues within the U.S. from customers domiciled in the U.S. Changes in interest rates, credit quality, economic trends and the capital markets are primary factors that drive the performance of the Bancorp. As discussed later in the Risk Management section of MD&A, risk identification, measurement, monitoring, control and reporting are important to the management of risk and to the financial performance and capital strength of the Bancorp.

Net interest income is the difference between interest income earned on assets such as loans, leases and securities, and interest expense incurred on liabilities such as deposits, short-term borrowings and long-term debt. Net interest income is affected by the general level of interest rates, the relative level of short-term and long-term interest rates, changes in interest rates and changes in the amount and composition of interest-earning assets and interest-bearing liabilities.

Noninterest income is derived from wealth and asset management revenue, commercial payments revenue, consumer banking revenue, capital markets fees, commercial banking revenue, mortgage banking net revenue, other noninterest income and net securities gains or losses. Noninterest expense includes compensation and benefits, technology and communications, net occupancy expense, card and processing expense, equipment expense, marketing expense, loan and lease expense and other noninterest expense.

Acquisition of Comerica Incorporated

On February 1, 2026, Fifth Third Bancorp closed the merger with Comerica Incorporated (“Comerica”) in an all-stock transaction valued at approximately $12.7 billion. Under the terms of the merger agreement, each outstanding share of Comerica’s common stock was converted into the right to receive 1.8663 shares of Fifth Third Bancorp common stock and each outstanding share of Comerica’s preferred stock was converted into the right to receive one share of a newly created series of preferred stock with comparable terms issued by the Bancorp.

On February 1, 2026, the Bancorp issued 16,000,000 depositary shares, representing 400,000 shares of 6.875% fixed-rate reset non-cumulative perpetual preferred stock, Series M to the holders of Comerica’s 6.875% fixed-rate reset non-cumulative perpetual preferred stock, Series B that were outstanding on January 30, 2026. Each Series M share has a $1,000 liquidation preference and accrues dividends on a non-cumulative quarterly basis, initially beginning on January 1, 2026 with a first dividend payment date of April 1, 2026. Subject to any required regulatory approval, the Bancorp may redeem the Series M preferred shares at its option, in whole or in part, on any dividend payment date on or after October 1, 2030 and may redeem, in whole but not in part, within 90 days following a regulatory capital event. The Series M preferred shares are not convertible into Bancorp common shares or any other securities.

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Management’s Discussion and Analysis of Financial Condition and Results of Operations (continued)

The Bancorp’s financial condition and results of operations as of, and for the three and nine months ended, September 30, 2026, were impacted by activity attributable to the Comerica acquisition and the integration of acquired operations, which affects the comparability of results between periods presented herein.

Refer to Note 4 of the Notes to Condensed Consolidated Financial Statements for more information.

Senior Notes Transactions

On January 29, 2026, the Bancorp issued and sold $1.0 billion of fixed-rate/floating-rate senior notes which will mature on April 29, 2032. The senior notes will bear interest at a rate of 4.566% per annum to, but excluding, April 29, 2031. From, and including, April 29, 2031, to, but excluding, the maturity date, the senior notes will bear interest at a rate of compounded SOFR plus 0.95%.

On January 29, 2026, the Bancorp issued and sold $1.0 billion of fixed-rate/floating-rate senior notes which will mature on January 29, 2037. The senior notes will bear interest at a rate of 5.141% per annum to, but excluding, January 29, 2036. From, and including, January 29, 2036 to, but excluding, the maturity date, the senior notes will bear interest at a rate of compounded SOFR plus 1.24%.

On June 10, 2026, the Bancorp completed exchange offers under which approximately $335 million of 4.00% senior notes due February 1, 2029, and approximately $938 million of fixed-rate/floating-rate senior notes due January 30, 2030, originally issued by Comerica Incorporated, were exchanged for new senior notes issued by the Bancorp with substantially identical terms. These notes were subsequently exchanged for registered senior notes on September 24, 2026.

Refer to Note 14 of the Notes to Condensed Consolidated Financial Statements for more information.

Category III Transition

In the third quarter of 2026, the Bancorp transitioned from Category IV to Category III standards. Under Category III standards, the Bancorp is subject to additional regulatory requirements and oversight, including enhanced liquidity monitoring through compliance with the liquidity coverage ratio and net stable funding ratio, while additional requirements including compliance with single-counterparty credit limits will need to be met. Compliance with the single-counterparty credit limits will be required beginning in the fourth quarter of 2028. The Bancorp continues to be required to develop and maintain an annual capital plan, which must be approved by the Board of Directors; however, as a Category III institution, it is subject to annual supervisory stress testing, including the recalibration of its stress capital buffer, a change from the Category IV biennial requirement.

Revisions to Supervisory Stress Testing Framework

On September 30, 2026, the FRB adopted revisions to its supervisory stress testing framework intended to enhance transparency and reduce volatility in stress capital buffer requirements. The revisions provide for annual public input on stress test scenarios and material model changes, shift the effective date of stress capital buffer requirements from October 1 to January 1 of the following year and introduce a two-year results averaging methodology for stress capital buffer requirements. The FRB will begin averaging supervisory stress test results in 2028, with the first stress capital buffer requirements calculated under the averaging methodology becoming effective January 1, 2029.

Proposed Updates to Regulatory Requirements for Capital

On March 19, 2026, the U.S. banking agencies issued notices of proposed rulemaking to revise the U.S. regulatory capital framework to finalize the post-crisis Basel III reforms. Comments were due by June 18, 2026 with final implementation expected to include a multi-year transition. The Bancorp and the Bank would not be required to adopt the new expanded risk‑based approach under the proposed rules, although the proposed rules would permit an election to adopt the expanded risk‑based approach. However, if implemented as proposed, the rules would impact how the Bancorp and the Bank calculate capital requirements. Effective dates for the proposed rules were not included in the proposal. Based upon the proposed rules, the Bancorp currently estimates that its CET1 risk-based capital ratio would be approximately 9.2% as of September 30, 2026.

Key Performance Indicators

The Bancorp, as a banking institution, utilizes various key indicators of financial condition and operating results in managing and monitoring the performance of the business. In addition to traditional financial metrics, such as revenue and expense trends, the Bancorp monitors other financial measures that assist in evaluating growth trends, capital and liquidity strength and operational efficiencies. The Bancorp analyzes these key performance indicators against its past performance, its forecasted performance and with the performance of its peer banking institutions. These indicators may change from time to time as the operating environment and businesses change. There have been no material changes made during the nine months ended September 30, 2026 to the Bancorp’s key performance indicators. Refer to the Bancorp’s Annual Report on Form 10-K for the year ended December 31, 2025 for more information.

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Management’s Discussion and Analysis of Financial Condition and Results of Operations (continued)

(a)Amounts presented on an FTE basis. The FTE adjustments were $5 for both the three months ended September 30, 2026 and 2025 and $15 for both the nine months ended September 30, 2026 and 2025.

(b)This is a non-GAAP measure. For further information, refer to the Non-GAAP Financial Measures section of MD&A.

Earnings Summary

Net interest income on an FTE basis (non-GAAP) increased $751 million and $2.0 billion for the three and nine months ended September 30, 2026, respectively, compared to the same periods in the prior year, reflecting the impact of the Comerica acquisition including $73.0 billion of interest-earning assets acquired as well as $48.2 billion of interest-bearing liabilities and $24.9 billion of noninterest-bearing liabilities assumed on February 1, 2026. Net interest income for the three and nine months ended September 30, 2026 benefited from higher average balances of interest-earning assets primarily driven by the Comerica acquisition, lower funding costs resulting from the benefit of lower short-term market rates and the repricing and reinvestment of fixed-rate assets to higher yields, including the securities repositioning during the second quarter of 2026. These benefits were partially offset by increases in interest expense primarily due to higher average balances of interest-bearing core deposits and long-term debt primarily driven by the Comerica acquisition as well as lower yields on average loans and leases and average other short-term investments resulting from lower short-term market rates. Additionally, net interest income for the three and nine months ended September 30, 2026 included $57 million and $160 million, respectively, of amortization and accretion of purchase accounting premiums and discounts related to the Comerica acquisition. Net interest margin on an FTE basis (non-GAAP) was 3.34% for both the three and nine months ended September 30, 2026 compared to 3.13% and 3.10% for the same periods in the prior year.

The provision for credit losses was $122 million and $479 million for the three and nine months ended September 30, 2026, respectively, compared to $197 million and $544 million during the same periods in the prior year. The decreases in provision expense for both the three and nine months ended September 30, 2026 included the impact of $178 million resulting from the fraud-related impairment of an asset-backed finance commercial loan in the third quarter of 2025. Provision expense for the three months ended September 30, 2026 was also affected by factors that caused a decrease in the ACL from June 30, 2026, including improvement in the economic forecast used to calculate

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Management’s Discussion and Analysis of Financial Condition and Results of Operations (continued)

the ACL, inclusive of a qualitative adjustment to reflect current economic conditions and outlook as of September 30, 2026, partially offset by improvement in the commercial risk profile as well as higher period-end portfolio loan and lease balances. Provision expense for the nine months ended September 30, 2026 was primarily driven by the initial recognition of the reserve for unfunded commitments assumed in the Comerica acquisition and higher period-end portfolio loan and lease balances, offset by improvement in the economic forecast used to calculate the ACL, inclusive of a qualitative adjustment to reflect current economic conditions and outlook as of September 30, 2026.

Noninterest income increased $227 million and $738 million for the three and nine months ended September 30, 2026, respectively, compared to the same periods in the prior year primarily driven by increases in commercial payments revenue, wealth and asset management revenue, capital markets fees, commercial banking revenue and consumer banking revenue. These increases were impacted by activity attributable to the Comerica acquisition and the integration of acquired operations.

Noninterest expense increased $782 million and $2.7 billion for the three and nine months ended September 30, 2026, respectively, compared to the same periods in the prior year primarily due to increases in compensation and benefits expense, technology and communications expense, net occupancy expense, card and processing expense, marketing expense and other noninterest expense. These increases included direct merger-related expenses as well as activity attributable to the Comerica acquisition and the integration of acquired operations.

For more information on net interest income, provision for credit losses, noninterest income and noninterest expense, including impacts of the Comerica acquisition, refer to the Statements of Income Analysis section of MD&A.